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News - Plungerless Pre-Filled Syringe aims to address drug delivery challenges

Image Credit: Avicenna Therapeutic Technologies.

April 2026 | Jack Overell, Head of Production, SAE Media Group

A newly developed prefilled syringe platform replaces the traditional plunger with magnetic propulsion, a design intended to improve drug stability, extend shelf life, and reduce costs across manufacturing and distribution.

A prefilled, disposable cartridge combined with a reusable injector platform under development by startup Avicenna Therapeutic Technologies is positioning itself as an alternative to conventional syringe designs used for therapeutic drugs and biologics.

The system features a sealed cartridge that eliminates the plunger, a change the company says could significantly improve drug stability and extend shelf life, potentially enabling longer patient expiry periods.

By increasing stability, the approach may also allow pharmaceutical manufacturers to produce medicines in larger batches, which could translate into lower production costs.

“The plunger-barrel design of presently commercially available prefilled syringes continues to pose many challenges,” says Boris Zubry, engineer, professor, inventor, and founder of the company. He says those challenges include drug stability, shelf life, silicon oil barrel coatings, leachables, extractables, storage, shipping, handling, cold chain management, logistics, medical disposal, air bubbles, overfill, leakage, breakage, drug availability (especially in remote areas), and cross-contamination.

Disposable Single-Use Cartridge

At the core of the platform is a disposable, single-use cartridge that is vacuum- or inert-gas-sealed, combined with the company’s patented Magnetic Injection Syringe Technology (MIST). The design is intended to support the dispensing and storage of liquids, viscous semi-liquids, and gases. The system is capable of operating in both directions, allowing materials to be injected or extracted, a feature that could support applications in R&D and field environments.

Rather than using an internal plunger, the cartridge is paired with a reusable injector that houses permanent magnets mounted externally. These magnets drive an inert, ferrous, Teflon-encapsulated piston inside the cartridge, enabling controlled displacement of the medication.

The self-lubricating piston minimizes the need for silicon oil lubricants inside the cartridge. Eliminating the plunger rod also enables the cartridge to remain sealed on both ends until use. According to the company, this design helps prevent environmental exposure and reduces the risk of leachable and extractable contaminants.

“Magnetically propelled (permanent magnets) fluid delivery is currently in use by many industrial applications,” Dr. Christopher Tirotta, Avicenna’s CEO said, adding that the same principles apply to the new design:

“Vacuum-sealed cartridges can help to dramatically increase product shelf life and better contain the escalating manufacturing, shipping, and storage costs generally associated with most conservative prefilled syringe systems. With this approach, one would be able to obtain and use the life-saving medication in the most remote areas.”

Multi-Use Injector Prototypes

The cartridge is designed as a standardized component that can be used across multiple injector formats, each incorporating the magnetic drive mechanism and eliminating the need for a traditional plunger and open syringe barrel.

In a multi-use injector configuration, medication is dispensed through a magnetically actuated ferrous piston. In addition to a pen-style injector, Zubry notes that Avicenna has also developed a gun-style injector with a trigger mechanism in response to partner interest. Injector designs can be adapted to suit specific use cases and branding requirements, with further refinements dependent on partner-led R&D and commercialization plans.

While several elements of the platform and packaging may vary based on a medtech company’s application, Avicenna has outlined a range of confirmed technical attributes and properties that define the system’s performance and compatibility.

Editor’s Corner



WHAT IS CPD?

CPD stands for Continuing Professional Development’. It is essentially a philosophy, which maintains that in order to be effective, learning should be organised and structured. The most common definition is:

‘A commitment to structured skills and knowledge enhancement for Personal or Professional competence’

CPD is a common requirement of individual membership with professional bodies and Institutes. Increasingly, employers also expect their staff to undertake regular CPD activities.

Undertaken over a period of time, CPD ensures that educational qualifications do not become obsolete, and allows for best practice and professional standards to be upheld.

CPD can be undertaken through a variety of learning activities including instructor led training courses, seminars and conferences, e:learning modules or structured reading.

CPD AND PROFESSIONAL INSTITUTES

There are approximately 470 institutes in the UK across all industry sectors, with a collective membership of circa 4 million professionals, and they all expect their members to undertake CPD.

For some institutes undertaking CPD is mandatory e.g. accountancy and law, and linked to a licence to practice, for others it’s obligatory. By ensuring that their members undertake CPD, the professional bodies seek to ensure that professional standards, legislative awareness and ethical practices are maintained.

CPD Schemes often run over the period of a year and the institutes generally provide online tools for their members to record and reflect on their CPD activities.

TYPICAL CPD SCHEMES AND RECORDING OF CPD (CPD points and hours)

Professional bodies and Institutes CPD schemes are either structured as ‘Input’ or ‘Output’ based.

‘Input’ based schemes list a precise number of CPD hours that individuals must achieve within a given time period. These schemes can also use different ‘currencies’ such as points, merits, units or credits, where an individual must accumulate the number required. These currencies are usually based on time i.e. 1 CPD point = 1 hour of learning.

‘Output’ based schemes are learner centred. They require individuals to set learning goals that align to professional competencies, or personal development objectives. These schemes also list different ways to achieve the learning goals e.g. training courses, seminars or e:learning, which enables an individual to complete their CPD through their preferred mode of learning.

The majority of Input and Output based schemes actively encourage individuals to seek appropriate CPD activities independently.

As a formal provider of CPD certified activities, SAE Media Group can provide an indication of the learning benefit gained and the typical completion. However, it is ultimately the responsibility of the delegate to evaluate their learning, and record it correctly in line with their professional body’s or employers requirements.

GLOBAL CPD

Increasingly, international and emerging markets are ‘professionalising’ their workforces and looking to the UK to benchmark educational standards. The undertaking of CPD is now increasingly expected of any individual employed within today’s global marketplace.

CPD Certificates

We can provide a certificate for all our accredited events. To request a CPD certificate for a conference , workshop, master classes you have attended please email events@saemediagroup.com

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