Epigenetic Profiling
7 December 2010
Epigenetic Profiling


This SAE Media Group masterclass will explore the application of epigenetic profiling technology in pharmaceutical development.

Epigenetics is the study of the regulation of gene expression through non-sequence based factors. It is what links our primary gene sequencing to our environment allowing for differential gene expression, environmental gene modulation, reversible expression and provision of certain inheritable traits. Therapeutics for cancer, neurodegenerative and infectious diseases based on epigenetic targets are already in development and research is underway to explore the role for epigenetics in cardiovascular, metabolic and other diseases.



Masterclass Agenda

  • Background to epigentics
  • Epigenetics in oncology and regenerative medicine
  • DNA methylation patterning
  • Epigenetic regulation 
  • Chromatin remodelling
  • The landscape for future profiling technologies 
Pharmacogenomic approach to personalised medicine        

About the Masterclass Leader


Mark Eccleston is the Managing Director of OncoLytika Ltd. He has previously worked for ValiRx Plc – an epigenetics based oncology company listed on AIM – and is a director of ValiFinn – a Finnish CRO offering epigenetic profiling services. He has set up several innovative companies in the biotechnology and fast moving consumer goods sector working in project management, preclinical development and business development. He has a PhD in Polymer Chemistry and an MBA from the University of Cambridge.


 About the Company  


  OncoLytika Ltd. is developing an in-house portfolio of therapeutic and imaging products and provides consultancy services to the Pharma and Biotech sectors in the areas of preclinical development and formulation including outsourced project management. Additional activities include due diligence, business planning support including opportunity recognition, market assessment and marketing plan development. www.oncolytika.com


Masterclass agenda



Registration and coffee



Epigenetics: The link between genes and their environment

  • Introduction to epigenetics
  • DNA Methylation patterning
  • Histone Modifications and Chromatin structure
  • Profiling technologies
  • clock


    Epigenetic regulation in stem cells and cancer

  • Epigentic regulation of transcription
  • Transcription and cancer
  • The cancer Epigenome
  • clock





    The Commercial epigenetic landscape

  • Market overview
  • Key Players and technologies
  • Case Studies
  • clock


    Emerging technologies and opportunities

  • Genome wide epigenetic profiling
  • Chromatin remodeling – therapeutic implications
  • clock


    Discussion and questions



    Close of masterclass


    Holiday Inn Bloomsbury

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    Holiday Inn Bloomsbury

    Coram Street
    London WC1N 1HT
    United Kingdom

    Holiday Inn Bloomsbury

    Holiday Inn London-Bloomsbury is just 2 minutes' walk from the Tube at Russell Square station, for speedy connections across the capital. We're 10 minutes by bus from Eurostar connections at St Pancras station, and a 45-minute taxi ride from London Heathrow Airport. Check into your stylish Guest room, air-conditioned and connected to wireless Internet.



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    CPD stands for Continuing Professional Development’. It is essentially a philosophy, which maintains that in order to be effective, learning should be organised and structured. The most common definition is:

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    CPD is a common requirement of individual membership with professional bodies and Institutes. Increasingly, employers also expect their staff to undertake regular CPD activities.

    Undertaken over a period of time, CPD ensures that educational qualifications do not become obsolete, and allows for best practice and professional standards to be upheld.

    CPD can be undertaken through a variety of learning activities including instructor led training courses, seminars and conferences, e:learning modules or structured reading.


    There are approximately 470 institutes in the UK across all industry sectors, with a collective membership of circa 4 million professionals, and they all expect their members to undertake CPD.

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    As a formal provider of CPD certified activities, SAE Media Group can provide an indication of the learning benefit gained and the typical completion. However, it is ultimately the responsibility of the delegate to evaluate their learning, and record it correctly in line with their professional body’s or employers requirements.


    Increasingly, international and emerging markets are ‘professionalising’ their workforces and looking to the UK to benchmark educational standards. The undertaking of CPD is now increasingly expected of any individual employed within today’s global marketplace.

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