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Asthma & COPD

Asthma and COPD together create an enormous public health burden and an urgent need for progress in disease understanding, therapy and care. Join us at SAE Media Group's 11th annual Asthma & COPD conference to share in the experiences of leading lights in the field who are addressing the challenges of solving the riddle of pathogenesis, biomarkers and endpoints, personalising therapies vs. the unmet need, tackling the causes and consequences of exacerbations, development of new animal models and better tools for disease diagnosis and monitoring.

This conference will give delegates invaluable insights into the key thinking and advances in the respiratory drug market, focusing on the challenges and solutions to enhance patient outcomes, providing extensive knowledge from the key leading industry, academic and care providing experts.

 

FEATURED SPEAKERS

Andrew Bush

Andrew Bush

Professor of Paediatric Respirology, Imperial College London and Royal Brompton Hospital
Joseph Arron

Joseph Arron

Associate Director, Biomarker Discovery, Genentech, Inc.
Neil C Thomson

Neil C Thomson

Professor of Respiratory Medicine, University of Glasgow
Robert Niven

Robert Niven

Senior Lecturer in Respiratory Medicine, University of Manchester

Andrew Bush

Professor of Paediatric Respirology, Imperial College London and Royal Brompton Hospital
Andrew Bush

Antonio Gomez-Munoz

Professor of Biochemistry and Molecular Biology, University of the Basque Country
Antonio Gomez-Munoz

Clare Lloyd

Professor of Respiratory Immunology, Imperial College London
Clare Lloyd

Dirk Smith

Scientific Director , Amgen
Dirk Smith

James Pinchin

Research Fellow, Horizon DERC, The University of Nottingham
James Pinchin

Jan-Anders Karlsson

CEO , Verona Pharma
Jan-Anders Karlsson

John Blakey

Senior Clinical Lecturer, Liverpool School of Tropical Medicine
John Blakey

John Hurst

Consultant in Respiratory Medicine, University College London
John Hurst

Joseph Arron

Associate Director, Biomarker Discovery, Genentech, Inc.
Joseph Arron

Kirsten Kaiser

Executive Vice President Medical & Regulatory Development, SkyePharma AG
Kirsten Kaiser

Maria Buxton

Consultant Respiratory Physiotherapist , London North West Healthcare NHS Trust
Maria Buxton

Mona Bafadhel

Senior Lecturer Respiratory Medicine & NIHR Post-Doctoral Fellow, University Of Oxford
Mona Bafadhel

Neil C Thomson

Professor of Respiratory Medicine, University of Glasgow
Neil C Thomson

Patrick Mallia

Senior Clinical Lecturer, Imperial College London
Patrick Mallia

Philip E Silkoff

Senior Director, Immunology, Pulmonary Disease Area, Janssen Inc
Philip E Silkoff

Robert Niven

Senior Lecturer in Respiratory Medicine, University of Manchester
Robert Niven

Roland Kolbeck

Respiratory, Inflammation & Autoimmunity, MedImmune
Roland  Kolbeck

Samantha Walker

Executive Director, Research & Policy, Asthma UK
Samantha Walker

Sebastian Johnston

Professor of Respiratory Medicine, National Heart and Lung Institute, Imperial College London
Sebastian Johnston

Sejal Saglani

Reader in Respiratory Paediatrics , Imperial College London
Sejal  Saglani

Staffan Edsbacker

Global Project Director and Associate Professor , AstraZeneca R&D Mölndal and University of Lund
Staffan Edsbacker

sponsors

Conference agenda

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8:30

Registration & Coffee

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9:00

Chairman's Opening Remarks

Sebastian Johnston

Sebastian Johnston, Professor of Respiratory Medicine, National Heart and Lung Institute, Imperial College London

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9:10

Children’s asthma treatments are like children’s clothes: make sure they fit

Andrew Bush

Andrew Bush, Professor of Paediatric Respirology, Imperial College London and Royal Brompton Hospital

• Severe asthma in children is pathophysiologically different to the adult disease
• Before reaching for the monoclonal, think: are the basics right?
• When assessing results: did they CONSORT with the right children
• Planning trials: does the cap fit?

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9:40

Unravelling mechanisms of asthma exacerbations and implications for the future

Sebastian Johnston

Sebastian Johnston, Professor of Respiratory Medicine, National Heart and Lung Institute, Imperial College London

• Aetiology of asthma exacerbations
• Deficient antiviral immunity in asthma
• Epithelial immune interactions in asthma exacerbations
• Implications for new therapies

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10:10

Morning Coffee

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10:40

Is neutrophilic/non-eosinophilic inflammation an appropriate therapeutic target in asthma?

Neil C Thomson

Neil C Thomson, Professor of Respiratory Medicine, University of Glasgow

• Which inflammatory phenotype to target: non-eosinophilic, neutrophilic, Th2-low?
• Trials and tribulations with licensed drugs including macrolides for treating neutrophilic/non-eosinophilic asthma
• Novel small molecules for treating neutrophilic/non-eosinophilic asthma
• Potential role for biological agents for treating neutrophilic/non-eosinophilic asthma

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11:10

Mechanisms mediating paediatric severe asthma: translational approaches

Sejal  Saglani

Sejal Saglani, Reader in Respiratory Paediatrics , Imperial College London

• Pathology of paediatric severe asthma: inflammation and remodelling
• Steroid responsiveness in severe disease
• Novel therapeutic targets
 

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11:40

Cytokine regulation of pulmonary inflammation and remodelling in asthma

Clare Lloyd

Clare Lloyd, Professor of Respiratory Immunology, Imperial College London

• Can asthma phenotypes be modelled in vivo?
• Is airway remodelling dependent on inflammation?
• How do genes and environment affect development of pathology?
• Novel therapeutic avenues
 

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12:10

Networking Lunch

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13:10

Changing role of patient charities in research – what can we offer?

Samantha Walker

Samantha Walker, Executive Director, Research & Policy, Asthma UK

• Benefits of working with charities to patients and wider society
• What value can patient charities bring to multi-partner collaborations?
• The Asthma UK approach to establishing research partnerships with industry
• Examples of large collaborative research programmes that Asthma UK is involved in and future ways of working

 

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13:40

Enabling targeted therapy for severe asthma through molecular phenotyping and biomarker development

Joseph Arron

Joseph Arron, Associate Director, Biomarker Discovery, Genentech, Inc.

• Asthma heterogeneity impacts target, patient, and outcome selection
• A clinically valid biomarker comprises both the thing being measured and the assay used to measure it
• How to prove biomarker selection hypotheses in clinical studies
• Beyond type 2 inflammation: new insights into asthma phenotypes

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14:10

New therapeutic approaches for asthma: It’s all about the airways

Dirk Smith

Dirk Smith, Scientific Director , Amgen

• New biology is emphasizing the importance of the epithelium and innate immune pathways as key orchestrators of asthma-associated pathology
• What clues have genetics provided regarding key pathways and risk factors?
• Asthma is not a single disease- the importance of stratification and biomarkers
• Emerging targets and biomarker approaches from the new science

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14:40

Eosinophilic inflammation and exacerbations of asthma and COPD: A fatal liaison

Roland  Kolbeck

Roland Kolbeck, Respiratory, Inflammation & Autoimmunity, MedImmune

• Management of acute exacerbations in Asthma and COPD
• The role of eosinophilic inflammation in Asthma and COPD
• Development of monoclonal antibodies for the management of severe Asthma and COPD
• The need for personalized health care
 

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15:10

Afternoon Tea

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15:40

Asthma and COPD phenotypes – how reliable are they?

Mona Bafadhel

Mona Bafadhel, Senior Lecturer Respiratory Medicine & NIHR Post-Doctoral Fellow, University Of Oxford

• Learning from cluster analyses
• Evidence for stable phenotypes
• Impact on therapy
 

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16:10

The ADEPT study: airways disease endotyping for personalised therapeutics in asthma and COPD

Philip E Silkoff

Philip E Silkoff, Senior Director, Immunology, Pulmonary Disease Area, Janssen Inc

• It’s clear not all drugs work in all people; are you surprised?
• Janssen wished to build up an internal database for asthma and COPD to interrogate current and future therapeutic targets
• We recruited 150 asthmatics and 30 healthy controls in PART 1 and 60 COPD and 60 healthy controls in Part 2. Most subjects had bronchoscopies
• We have already gained great insights and the analysis has only just begun!
 

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16:40

Chairman’s Closing Remarks and Close of Day One

Sebastian Johnston

Sebastian Johnston, Professor of Respiratory Medicine, National Heart and Lung Institute, Imperial College London

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8:30

Registration & Coffee

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9:00

Chairman's Opening Remarks

Robert Niven

Robert Niven, Senior Lecturer in Respiratory Medicine, University of Manchester

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9:10

Ceramide 1-phosphate (C1P), a potential new therapeutic target for COPD

Antonio Gomez-Munoz

Antonio Gomez-Munoz, Professor of Biochemistry and Molecular Biology, University of the Basque Country

• C1P reduces lung inflammation
• C1P promotes cell growth, survival and migration
• The mechanism whereby C1P exerts its anti-inflammatory actions involve inhibition of sphingomyelinase and serine palmitoyl transferase activities, reduction of pro-inflammatory cytokines, and inhibition of NF-kB
• C1P analogs are promising tools for developing new strategies to treat COPD

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9:50

Viruses in asthma and COPD

Patrick Mallia

Patrick Mallia, Senior Clinical Lecturer, Imperial College London

• Contribution of viruses to exacerbations in asthma and COPD
• Mechanisms of virus-induced exacerbations
• Viral/bacterial co-infection
• Future developments

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10:20

Drug development challenges associated with inhaled and intranasal antivirals

Staffan Edsbacker

Staffan Edsbacker, Global Project Director and Associate Professor , AstraZeneca R&D Mölndal and University of Lund

• Device and dosing considerations
• Indication and patient segmentation
• Trial setting and endpoints
 

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10:50

Morning Coffee

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11:20

Round Table Discussion: Challenges and choices in stratified asthma therapeutics

Robert Niven

Robert Niven, Senior Lecturer in Respiratory Medicine, University of Manchester

  • How many interleukin targeting MABS will be enough?
  • What are the unmet needs in asthma and what is the future for these groups?
  • clock

    11:50

    Always on, always with you. The role of personal technology and the digital economy in respiratory health

    • Why will we see increasingly widespread adoption of new personal health technologies?
    • There’s an app for that: medical “apps” are likely to have a significant role in respiratory health in the future
    • Google knows, do you? The trail left by your daily interactions contains valuable health related data
    • Discuss examples of smart devices (including smart inhalers) providing information that isn’t apparent to healthcare professionals
     

    John Blakey

    John Blakey, Senior Clinical Lecturer, Liverpool School of Tropical Medicine

    James Pinchin

    James Pinchin, Research Fellow, Horizon DERC, The University of Nottingham

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    12:30

    Networking Lunch

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    13:30

    RPL554 as a novel treatment for severe COPD

    Jan-Anders Karlsson

    Jan-Anders Karlsson, CEO , Verona Pharma

    • Unmet medical need in COPD
    • RPL554 as a treatment of COPD exacerbations
    • Additional potential indications for RPL554
     

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    14:30

    Afternoon Tea

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    15:00

    Pulmonary rehabilitation in the real world

    Maria Buxton

    Maria Buxton, Consultant Respiratory Physiotherapist , London North West Healthcare NHS Trust

    • Research vs Real Life
    • Drop out – is there an answer?
    • Mapping PR in London
    • Commissioning PR
     

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    15:30

    COPD: Unmet need and challenges in NHS Care

    John Hurst

    John Hurst, Consultant in Respiratory Medicine, University College London

    • What are the key areas of unmet clinical need for COPD clinical care?
    • What are the barriers to access for new drugs in current NHS practice?
    • Who is prescribing new drugs in the NHS?
    • Which aspects of COPD urgently require new pharmaceutical approaches?

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    16:00

    Chairman’s Closing Remarks and Close of Day Two


    Professor of Paediatric Respirology
    Imperial College London and Royal Brompton Hospital
    Professor of Biochemistry and Molecular Biology
    University of the Basque Country
    Professor of Respiratory Immunology
    Imperial College London
    Scientific Director
    Amgen
    Research Fellow, Horizon DERC
    The University of Nottingham
    CEO
    Verona Pharma
    Senior Clinical Lecturer
    Liverpool School of Tropical Medicine
    Consultant in Respiratory Medicine
    University College London
    Associate Director, Biomarker Discovery
    Genentech, Inc.
    Executive Vice President Medical & Regulatory Development
    SkyePharma AG
    Consultant Respiratory Physiotherapist
    London North West Healthcare NHS Trust
    Senior Lecturer Respiratory Medicine & NIHR Post-Doctoral Fellow
    University Of Oxford
    Professor of Respiratory Medicine
    University of Glasgow
    Senior Clinical Lecturer
    Imperial College London
    Senior Director, Immunology, Pulmonary Disease Area
    Janssen Inc
    Senior Lecturer in Respiratory Medicine
    University of Manchester
    Respiratory, Inflammation & Autoimmunity
    MedImmune
    Executive Director, Research & Policy
    Asthma UK
    Professor of Respiratory Medicine
    National Heart and Lung Institute, Imperial College London
    Reader in Respiratory Paediatrics
    Imperial College London
    Global Project Director and Associate Professor
    AstraZeneca R&D Mölndal and University of Lund

    Sponsors and Exhibitors

    Official Media Partner

    Supporters

    Attendee List for Asthma & COPD

    Download

    Quick Fire Q&A with Janssen pulmonary disease specialist

    Download

    A spotlight on Asthma & COPD with Joseph Arron, Genentech

    Download

    Sponsors and Exhibitors


    Artimmune

    Sponsors and Exhibitors
    http://www.artimmune.com

    ArtImmune is a contract research company which offers consulting and preclinical research services in immunology and inflammation with an emphasis on lung diseases. ArtImmune has a strong expertise in preclinical investigations of lung functions in vivo including plethysmography, bronchoalveolar lavage, cytology, histology, immunohistochemistry, and analysis of biochemical, immunological and molecular parameters.

    Media Partners


    BioMed Central - Respiratory Research

    Official Media Partner
    http://respiratory-research.com/

    Respiratory Research is an open access journal aiming at publishing high-quality science in all areas of respiratory disease. Topics of specific interest include asthma, chronic obstructive pulmonary disease, cystic fibrosis, genetics, infectious diseases, interstitial lung diseases, lung development, lung tumors, occupational and environmental factors, pulmonary circulation, pulmonary pharmacology and therapeutics, respiratory immunology, respiratory physiology, and sleep-related respiratory problems.


    BioMed Central - Cough

    Official Media Partner
    http://www.coughjournal.com/

    Cough is an open access, peer-reviewed, online journal encompassing the scientific and clinical aspects of both acute and chronic cough.


    BioMed Central - COPD Research and Practice

    Official Media Partner
    http://www.copdrp.com/

    BioMed Central is an online STM publisher of more than 270 peer-reviewed open access journals. The portfolio of journals spans all areas of biology, biomedicine and medicine, with many journals publishing content related to pulmonary medicine and allergy research. Examples of such journals include: COPD Research and Practice, Multidisciplinary Respiratory Medicine, Respiratory Research, and Allergy, Asthma & Clinical Immunology. All original research articles published by BioMed Central are made freely accessible online immediately upon publication. Authors publishing with BioMed Central retain copyright of their work, licensing it under the Creative Commons Attribution License which allows articles to be re-used and re-distributed without restriction, as long as the original work is correctly cited. BioMed Central is owned by Springer Science+Business Media, and also hosts the SpringerOpen platform.


    BioMed Central - Asthma Research and Practice

    Official Media Partner
    http://www.asthmarp.com/

    Asthma Research and Practice will publish articles related to basic asthma research, clinical practice as well as translational research. The journal aims to publish the most recent and relevant information on asthma and related disorders (such as rhinitis, COPD overlapping syndrome, sinusitis).


    BioMed Central - BMC Pulmonary Medicine

    Official Media Partner
    http://www.biomedcentral.com/bmcpulmmed

    BMC Pulmonary Medicine is an open access, peer-reviewed journal that considers articles on all aspects of the prevention, diagnosis and management of pulmonary and associated disorders, as well as related molecular genetics, pathophysiology, and epidemiology.

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    Drug Discovery Today

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    KONGPOSH Publications

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    KONGPOSH Publications is one of India’s leading Pharma Publishers. The Pharma Review® is a bi-monthly article based journal covering various fields of pharmacy. Participation and distribution in over 30 Expos & Conferences worldwide each year. It is widely read by decision makers, middle management and the academia. Also available in E-book format. Other publications : Indian Pharma Reference Guide (Annual) – Names and address of Pharmaceuticals, Bulk Drugs, Machinery’s & Instrumentation, AYUSH Manufacturers; and much more; High Performance Thin Layer Chromatography; Elements of Pharmacovigilance; Regulation of Clinical Trials; AYUSH (CD); NDDS/AMD (CD)


    PharmaVOICE

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    PharmaVOICE magazine, and its supporting VIEW publications, provide commentary about the challenges and trends impacting the life-sciences industry, covering a range of issues from molecule through market. PharmaVOICE's more than 41,000 U.S.-based subscribers are also kept abreast of the latest trends through additional media resources, including WebSeminars, Podcasts, Videocasts, and White Papers.


    British Pharmacological Society

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    PharmCast

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    Technology Networks

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    Labsave

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    http://www.swissbiotech.org/

    The Swiss Biotech Association (SBA) is the national industry association for biotechnology, including pharmaceuticals, diagnostics, agriculture, food, cosmetics, environmental biotechnology, and specialty chemicals. Members are companies active in modern biotechnology, such as R&D, Production, Marketing and Sales, Finance, Services and Consulting. SBA provides a networking platform for Life Science clusters, academic and federal institutions the like. Founded in March 1998, the Association grows steadily.


    Biosave

    Supporters
    http://www.Biosave.com

    Biosave.com brings together the best Life Science promotions, product releases, featured products, publications, videos and events from 100’s of leading Life Science suppliers. Updated 24 hours a day, Biosave is constantly uploading special promotions and exciting product news that you won’t find anywhere else. Our goal is to provide our users with the most exclusive product information to help reach that all important purchasing decision.


    Bioscreening

    Supporters
    http://www.bioscreening.com



    PMR

    Supporters
    http://www.pmrcorporate.com

    PMR (www.pmrcorporate.com) is a British-American company providing market information, advice and services to international businesses interested in Central and Eastern European countries as well as other emerging markets. PMR's key areas of operation include business publications (through PMR Publications), consultancy (through PMR Consulting) and market research (through PMR Research ). Being present on the market since 1995, offering high international standards in projects and publications, as well as providing one of the most frequently visited and top-ranked websites, PMR is one of the largest companies of its type in the region.

    Holiday Inn Regents Park

    Carburton Street
    London W1W 5EE
    United Kingdom

    Holiday Inn Regents Park

    Choose the well-connected Holiday Inn London-Regent's Park hotel, with a superb central London location and speedy transport links. Holiday Inn London-Regent's Park is in a leafy and cosmopolitan area of central London, a 10-minute walk from bustling Oxford Street. Leave your car in our NCP managed underground car park, and explore London by Tube. Great Portland Street Tube station is 25 metres from the hotel, from where you can reach the City and Canary Wharf in 30 minutes, and London Heathrow Airport in 45 minutes.

    Wireless Internet is available throughout the hotel, and you can invite up to 300 people to events at the Academy Conference Centre, with an IT technician and break-out zones. Holiday Inn London-Regent's Park is a 10-minute walk from Santander's offices and businesses in the BT Tower. Stroll 5 minutes to Regent's Park, where you'll find London Zoo and pretty Primrose Hill. We're a 10-minute walk from Bond Street boutiques and 20 minutes from Buckingham Palace and cruises on the River Thames.

    Ask our Concierge to plan your day out and book West End theatre tickets. Room Service is available 24 hours at Holiday Inn London-Regent's Park, or dine in the vibrant Junction Restaurant. Our Junction Bar has a menu of light bites, and a hot breakfast buffet is served daily.

    HOTEL BOOKING FORM

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    WHAT IS CPD?

    CPD stands for Continuing Professional Development’. It is essentially a philosophy, which maintains that in order to be effective, learning should be organised and structured. The most common definition is:

    ‘A commitment to structured skills and knowledge enhancement for Personal or Professional competence’

    CPD is a common requirement of individual membership with professional bodies and Institutes. Increasingly, employers also expect their staff to undertake regular CPD activities.

    Undertaken over a period of time, CPD ensures that educational qualifications do not become obsolete, and allows for best practice and professional standards to be upheld.

    CPD can be undertaken through a variety of learning activities including instructor led training courses, seminars and conferences, e:learning modules or structured reading.

    CPD AND PROFESSIONAL INSTITUTES

    There are approximately 470 institutes in the UK across all industry sectors, with a collective membership of circa 4 million professionals, and they all expect their members to undertake CPD.

    For some institutes undertaking CPD is mandatory e.g. accountancy and law, and linked to a licence to practice, for others it’s obligatory. By ensuring that their members undertake CPD, the professional bodies seek to ensure that professional standards, legislative awareness and ethical practices are maintained.

    CPD Schemes often run over the period of a year and the institutes generally provide online tools for their members to record and reflect on their CPD activities.

    TYPICAL CPD SCHEMES AND RECORDING OF CPD (CPD points and hours)

    Professional bodies and Institutes CPD schemes are either structured as ‘Input’ or ‘Output’ based.

    ‘Input’ based schemes list a precise number of CPD hours that individuals must achieve within a given time period. These schemes can also use different ‘currencies’ such as points, merits, units or credits, where an individual must accumulate the number required. These currencies are usually based on time i.e. 1 CPD point = 1 hour of learning.

    ‘Output’ based schemes are learner centred. They require individuals to set learning goals that align to professional competencies, or personal development objectives. These schemes also list different ways to achieve the learning goals e.g. training courses, seminars or e:learning, which enables an individual to complete their CPD through their preferred mode of learning.

    The majority of Input and Output based schemes actively encourage individuals to seek appropriate CPD activities independently.

    As a formal provider of CPD certified activities, SAE Media Group can provide an indication of the learning benefit gained and the typical completion. However, it is ultimately the responsibility of the delegate to evaluate their learning, and record it correctly in line with their professional body’s or employers requirements.

    GLOBAL CPD

    Increasingly, international and emerging markets are ‘professionalising’ their workforces and looking to the UK to benchmark educational standards. The undertaking of CPD is now increasingly expected of any individual employed within today’s global marketplace.

    CPD Certificates

    We can provide a certificate for all our accredited events. To request a CPD certificate for a conference , workshop, master classes you have attended please email events@saemediagroup.com

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    Contact SAE Media Group

    UK Office
    Opening Hours: 9.00 - 17.30 (local time)
    SAE Media Group , Ground Floor, India House, 45 Curlew Street, London, SE1 2ND, United Kingdom
    Tel: +44 (0) 20 7827 6000 Fax: +44 (0) 20 7827 6001
    Website: http://www.smgconferences.com Email: events@saemediagroup.com
    Registered in England - SMi Group Ltd trading as SAE Media Group




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