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Psychiatric Disorders
24 May - 25 May 2004
Psychiatric Disorders
Psychiatric disorders, most notably depression, are one of the largest growth areas in CNS medicine, representing an extremely lucrative market for the pharmaceutical industry. However, finding novel compounds offering significant advantages over what is already on the market for psychiatric disorders is not easy. With several key antidepressants and anti-anxiety drugs due to come off patent by 2008, pharmaceutical companies are searching for compounds with new modes of action, looking to find faster-acting therapies with fewer side effects and solutions for treatment-resistant patients.

This Conference will evaluate the progress in treatment of depression, anxiety, bipolar disorder and schizophrenia, providing cutting edge information on the most exciting compounds currently in the pipeline. The event will also include discussion on some of the difficulties of clinical development in this field and will assess how these challenges can be addressed. It will include a look at conducting proof of principal studies, clinical trial design, patient recruitment issues and combination treatments.

A unique opportunity to learn from leading industry experts including:
· Dr Amir Kalali, Global Scientific Head, CNS Therapeutics, Quintiles
· Dr Jeffrey Sprouse, Neuropharmacologist, Team Leader, Antidepressant Programme, Pfizer
· Dr Phil Skolnick, Senior Vice President, Research & Chief Scientific Officer, Dov Pharmaceuticals
· Dr Thomas Blackburn, Senior Director, Medical Affairs, H Lundbeck
· Professor Tonmoy Sharma, Director, Clinical Neuroscience Research Centre

The essential event on:
· TREATING PSYCHIATRIC DISORDERS: Evaluate current progress in the treatment and understanding of depression, anxiety, bipolar disorder and schizophrenia
· THE LATEST IN CLINICAL DEVELOPMENTS: Understand cutting edge information on the most exciting compounds currently in the pipeline
· CLINICAL CHALLENGES: Discover some of the difficulties of clinical developments and how these challenges can be overcome
· KEY INDUSTRY PERSONNEL: Meet the leaders in the field and learn from their experiences

"This was a very interesting, useful and relevant conference. I am really glad I was able to participate."
Dr Phil Skolnick, Vice President, Research & Chief Scientific Officer, Dov Pharmaceutical, SAE Media Group’s Depression & Anxiety Conference 2003

Conference agenda

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8:30

Registration and Coffee

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9:00

Chairman's Opening Remarks

Dr Geoffrey Dunbar

Dr Geoffrey Dunbar, Vice President, Clinical Development & Regulatory Affairs, Targacept

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9:10

BIOMONITORING IN DRUG DISCOVERY RESEARCH FOR AFFECTIVE SPECTRUM DISORDERS

Dr Pim Drinkenburg

Dr Pim Drinkenburg, Principle Scientist & Head, Biomonitoring Research, Johnson & Johnson

  • Prediction of clinical efficacy: usefulness of EEG and in vivo microdialysis studies
  • Bridging preclinical and clinical psychiatric drug discovery research
  • Sleep-wake studies and circadian in antidepressant treatments
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    9:40

    PSYCHIATRIC CLINICAL TRIAL DESIGN

    Dr Amir Kalali

    Dr Amir Kalali, Global Scientific Head, CNS Therapeutics, Quintiles

  • Challenges in clinical development
  • Possible ways to reduce the risk of failure
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    10:20

    SIGNAL DETECTION IN CLINICAL TRIALS

    Dr Craig Mallinckrodt

    Dr Craig Mallinckrodt, Eli Lilly,

  • Lessons to be learnt from previous clinical trials
  • Variability of placebo response, lack of value of single blind ‘lead in’ periods and the effect of severity at entry revealing pertinent insights into the success of clinical trials
  • Prospective efforts to better understand placebo response
  • Enlarging and sharing relevant databases across centres and companies
  • Government, industries and academic collaborations to evaluate novel antidepressants
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    11:00

    Morning Coffee

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    11:20

    PANEL DISCUSSION

    Dr Jeffrey Sprouse

    Dr Jeffrey Sprouse, Associate Research Fellow, Pfizer

    Dr Thomas Blackburn

    Dr Thomas Blackburn, Senior Director, Medical Affairs, H Lundbeck

    Dr Cesare Mondadori

    Dr Cesare Mondadori, Chief Scientific Officer, Neuro3d

    Dr Paolo Bettica

    Dr Paolo Bettica, Director, Clinical Pharmacology & Discovery Medicine, Psychiatry CEDD, GlaxoSmithKline

    Professor Hermann Fuder

    Professor Hermann Fuder, Vice President & Principal Consultant, Clinical Pharmacology, Parexel

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    12:00

    CHARACTERISING AND TREATING TREATMENT RESISTANCE DEPRESSION

    Prof Tonmoy Sharma, Director, Clinical Neuroscience Research Centre

  • Associated problems: under-recognition of the deficits
  • The cognitive deficits in depression
  • State vs trait
  • Current tools to accurately characterise cognitive dysfunction
  • Therapeutic options for the treatment of depression including Monotherapy, Electroconvulsive Therapy (ECT), psychotherapy, combination strategies and augmentation strategies
  • New approaches: antipsychotic drugs and treatment resistance
    Novel antipsychotics and their effects on treatment resistant depression including cognitive deficits
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    12:40

    Networking Lunch

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    14:00

    DEVELOPMENT OF FIXED DOSE COMBINATIONS IN DEPRESSION AND ANXIETY

    Dr Paolo Bettica

    Dr Paolo Bettica, Director, Clinical Pharmacology & Discovery Medicine, Psychiatry CEDD, GlaxoSmithKline

  • Advantages and limitations of the current antidepressants and anxiolytics
  • Potential improvements of new antidepressants and anxiolytics in development
  • Should we develop a fixed dose combination for the treatment of depression and anxiety?
  • Regulatory implications in the development of a fixed dose combination for depression and anxiety
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    14:40

    BIPOLAR DISORDER

    Dr Charles Large

    Dr Charles Large, Head, Electrophysiology, GlaxoSmithKline

  • Current methods of diagnosis
  • Epidemiology of bipolar disorder
  • Classification of bipolar disorder: the choice of biological treatment
  • Clinical states and course specifiers: implications for treatment
  • Future mood stabilising and superior antidepressant properties
  • The long term management of bipolar disorder
    Lamictal sodium channel inhibitor bipolar disorder: a case study
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    15:20

    NOVEL CONCEPTS OF SCHIZOPHRENIA TREATMENTS

    Prof Hermann Fuder

    Prof Hermann Fuder, President & Principal Consultant Clinical Pharmacology, Parexel

  • Unmet needs in the treatment of schizophrenics
  • Profile of typical and atypical antipsychotics
  • Positive, negative symptoms vs cognition
  • Treatment with glycine
  • Glycine uptake inhibition
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    16:00

    Chairman's Closing Remarks and Close of Day One

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    8:30

    Re-registration and Coffee

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    9:00

    Chairman's Opening Remarks

    Prof Hermann Fuder

    Prof Hermann Fuder, President & Principal Consultant Clinical Pharmacology, Parexel

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    9:10

    GABAA RECEPTOR SUBTYPE-SELECTIVE MODULATORS

    Dr John Atack

    Dr John Atack, Senior Investigator, Merck Sharp & Dohme

  • Generalised Anxiety Disorder (GAD) – the nature of the problem
  • Current treatments for GAD and their limitations
  • Benzodiazepines and GABBAA receptors
  • Which GABAA subtypes are associated with anxiety?
  • Characteristics of a GABAA subtype-selective non-sedating anxiolytic
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    9:40

    SCHIZOPHRENIA: SELECTING THE RIGHT PHARMACOLOGICAL TARGET

    Dr Cesare Mondadori

    Dr Cesare Mondadori, Chief Scientific Officer, Neuro3d

  • New targets, hopes and reality
  • Drug discovery in small companies
  • Can we learn from history
  • Outlook
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    10:20

    CLINICAL DEVELOPMENT OF ANTIDEPRESSANTS

    Dr Rico Nil

    Dr Rico Nil, Regional Medical Director, H Lundbeck

  • Depression: diagnostics issues
  • Treatment of depression
  • Unmet needs
  • The placebo problem
  • Guidelines
  • The clinical development plan
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    11:00

    Morning Coffee

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    11:20

    SEROTONIN AUTORECEPTOR ANTAGONISTS IN DEPRESSION

    Dr Jeffrey Sprouse

    Dr Jeffrey Sprouse, Associate Research Fellow, Pfizer

  • The development of 5-HT1B antagonists: proof of concept data from the laboratory
  • Potential advantages due to the blockade of autoreceptors and hetoreceptors that modulate transmitter release
  • A drug discovery approach both unprecedented and precedented
  • Future prospects including combination therapies
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    12:00

    A TRIPLE UPTAKE INHIBITOR

    Dr Phil Skolnick

    Dr Phil Skolnick, Senior Vice President, Research & Chief Scientific Officer, DOV Pharmaceutical

  • Triple uptake inhibitor affecting the neurotransmitters norepinephrine, serotonin and dopamine
  • Preclinical promises: potently inhibiting the uptake of all three neurotransmitters
  • Fast acting-fast healing?
  • Safety, tolerability and PK profile
  • Looking towards phase II: multi-centred, doubleblind, safety, efficacy and tolerability clinical trial
  • Feasible comparisons to leading SSRI in patients with major depressive disorder?
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    12:40

    Networking Lunch

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    14:40

    NEUROPEPTIDES IN PSYCHIATRIC DISORDERS

    Dr Thomas Blackburn

    Dr Thomas Blackburn, Senior Director, Medical Affairs, H Lundbeck

  • Neuropeptides: attractive therapeutic targets for depression and anxiety disorders
  • The list of potential targets is ever increasing (NK1, CRF, vasopressin, MCH, NPY and galanin)
  • Clinical assessment of several compounds is currently underway and will be discussed
  • Where have we come from and what does the future hold?
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    14:40

    NEURODEGENERATION IN DEPRESSION

    Dr Roger Pinder

    Dr Roger Pinder, Vice President, Medical Affairs, CNS & Thrombosis, Organon International

  • HPA axis dysfunction in depression
  • Hippocampal changes in depression
  • Antidepressants and HPA axis function
  • Glucorticoid receptor antagonists as antidepressants
  • Reversal of hippocampal atrophy
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    15:20

    NEURONAL NICOTINIC RECEPTOR (NNR) MODULATION IN THE TREATMENT OF ANXIETY AND DEPRESSION

    Dr Geoffrey Dunbar

    Dr Geoffrey Dunbar, Vice President, Clinical Development & Regulatory Affairs, Targacept

  • Present anti-depressant and anti-anxiety treatments are inadequate
  • The NNR agonist nicotine has a long history of use in treating symptoms of anxiety and depression
  • Older molecules have failed in the clinic because of peripheral side effects
  • Present generation of compounds are CNS selective and offer a possible new therapeutic approach
  • Increased speed of onset of action is a real possibility
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    15:20

    Afternoon Tea

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    16:00

    Chairman’s Closing Remarks and Close of Conference

    The Hatton, at etc. venues

    51/53 Hatton Garden
    London EC1N 8HN
    United Kingdom

    The Hatton, at etc. venues

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    WHAT IS CPD?

    CPD stands for Continuing Professional Development’. It is essentially a philosophy, which maintains that in order to be effective, learning should be organised and structured. The most common definition is:

    ‘A commitment to structured skills and knowledge enhancement for Personal or Professional competence’

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    CPD can be undertaken through a variety of learning activities including instructor led training courses, seminars and conferences, e:learning modules or structured reading.

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    CPD Schemes often run over the period of a year and the institutes generally provide online tools for their members to record and reflect on their CPD activities.

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    GLOBAL CPD

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