Home
Immunogenicity

SAE Media Group is proud to announce the return of their 3rd annual Immunogenicity event to London in 2016!  Biologics is a leading growth area in the Pharmaceutical industry with growth rates 2 -3 times as fast as chemical entities.* The challenges for the biopharmaceutical market are different to those from traditional chemical entities. Immunogenicity continues to be a major concern for the field of science, due to its impact on safety and efficacy. The challenging task of immunogenicity assessment of a biopharmaceutical drug’s immunogenic potential remains at the forefront of challenges.


Immunogenicity of an antigen is frequently encountered in the context of vaccine development, an area of intense interest currently due to the emergence or re-emergence of infectious pathogens with the potential for worldwide spread. With the global vaccine market expected to reach $84.44 billion by 2022, now is the time engage with industry experts to addresses the real challenges with immunogenicity including assay assessment, the role of aggregation, the introduction of nanobodies and many more!
 


*http://www.biosciencetechnology.com/articles/2010/06/top-trends-life-science-need-immunogenicity-testing
 

FEATURED SPEAKERS

Adnan Khan

Adnan Khan

Senior Scientist Immunology/Pharmacology, UCB
Daniel  Sikkema

Daniel Sikkema

Head BioPharma Clinical Immunology, GSK
Jochem Gokemeijer

Jochem Gokemeijer

Associate Director, Bristol Myers Squibb

Adnan Khan

Senior Scientist Immunology/Pharmacology, UCB
Adnan Khan

Andreas Herrmann

CEO, Baliopharm AG
Andreas Herrmann

Annie De Groot

CEO/CSO, EpiVax, Inc.
Annie De Groot

Chloe Ackaert

Postdoctoral Researcher, Cellular and Molecular Immunology, Free University Of Brussels
Chloe Ackaert

Cornelis Melief

Chief Scientific Officer, ISA Pharmaceuticals
Cornelis  Melief

Daniel Sikkema

Head BioPharma Clinical Immunology, GSK
Daniel  Sikkema

Jeremy Derrick

Professor, University Of Manchester
Jeremy Derrick

Jeremy Fry

Director of Sales, ProImmune Ltd.
Jeremy Fry

Jochem Gokemeijer

Associate Director, Bristol Myers Squibb
Jochem Gokemeijer

Machteld Tiemessen

Senior Scientist, Janssen
Machteld Tiemessen

Mantas Malisauskas

Manager R&D, Baxalta
Mantas  Malisauskas

Mark Fogg

Immunology Group Leader, Abzena
Mark Fogg

Meenu Wadhwa

Head, Cytokines & Growth Factors, Biotherapeutics Group, , NIBSC, MHRA
Meenu Wadhwa

Petr Ilyinskii

Director of Biology , Selecta Biosciences
Petr Ilyinskii

Sue Charlton

Scientific Lead, Vaccine Research Group, , Public Health England
Sue Charlton

Timothy Hickling

Immunogenicity Sciences Discipline Lead, Pfizer Pharmaceuticals
Timothy Hickling

sponsors

Conference agenda

clock

8:30

Registration & Coffee

clock

9:00

Chairman's Opening Remarks

Jeremy Fry

Jeremy Fry, Director of Sales, ProImmune Ltd.

clock

9:10

Improving the efficacy and safety profile of biotherapeutics by addressing product immunogenicity with tolerogenic nanoparticles

Petr Ilyinskii

Petr Ilyinskii, Director of Biology , Selecta Biosciences

• The development of anti-drug antibodies (ADAs) is a common cause for treatment failure and adverse events associated with biologic therapies. 
• Addressing product immunogenicity has the potential to improve efficacy and safety profile of novel biologics; reduce catastrophic late stage clinical failure due to ADAs; provide life cycle management for existing products; and differentiate products from biosimilars.
• Selecta Biosciences is a clinical stage company that has developed a novel platform of Synthetic Vaccine Particles (SVP) to induce durable antigen-specific immune tolerance for the prevention of ADAs
 

clock

9:50

How to switch off unwanted immune responses

Adnan Khan

Adnan Khan, Senior Scientist Immunology/Pharmacology, UCB


• Is it possible to switch off an unwanted immune response?
• Revealing the mechanisms of tolerance induction are now being revealed
• Novel insights into tolerance induction with peptide antigens
 

clock

10:30

Morning Coffee

clock

11:00

A harmonised approach to interpretation and reporting of clinical immunogenicity data

Daniel  Sikkema

Daniel Sikkema, Head BioPharma Clinical Immunology, GSK


• How can we harmonise data?
• Should we be able to compare trial results that use different ranking methods
• The benefits a harmonised approach can bring to the reporting of clinical immunogenicity data
 

clock

11:40

Towards harmonisation of immunogenicity assays

Meenu Wadhwa

Meenu Wadhwa, Head, Cytokines & Growth Factors, Biotherapeutics Group, , NIBSC, MHRA


• Wide variation in ADA incidence and titres often reported for a therapeutic
• Should we produce reference panels or standardise methods to harmonise data?
• Availability of a WHO reference panel for erythropoietin antibody assays
 

clock

12:20

Networking Lunch

clock

13:30

Integrating best-in-class in vitro and ex vivo assays to manage immunogenicity risk in biologics

Jeremy Fry

Jeremy Fry, Director of Sales, ProImmune Ltd.

• Learn how data from cell-based assays, physical MHC-peptide binding assays and mass spectrometry antigen presentation assays can be integrated to characterise immune responses against, or caused by, biotherapeutic drugs
• Mitigate the risk of first infusion reactions using whole-blood cytokine release assays.
• Improve decision-making in lead selection, lead characterisation and re-engineering options
 

clock

14:10

Nanobodies, a promising new class of biopharmaceuticals: What about their immunogenicity?

Chloe Ackaert

Chloe Ackaert, Postdoctoral Researcher, Cellular and Molecular Immunology, Free University Of Brussels

• Nanobodies originate from camelids, but does their humanisation make sense?
• Different methods for ADA assessment towards nanobodies
• In vitro immunogenicity risk assessment of nanobodies
 

clock

14:50

Afternoon Tea

clock

15:20

Understanding the role of aggregation in the immunogenicity of biotherapeutic proteins

Jeremy Derrick

Jeremy Derrick, Professor, University Of Manchester

  • Comparison of the immunological responses to immunisation with recombinant biologics in monomeric and aggregated forms in a mouse model
  • The results were generally indicative of skewing towards a Th1-type response
  • Can HCPs also play a role in modulating the immune response?

     

  • clock

    16:20

    Chairman’s Closing Remarks and Close of Day One

    Annie De Groot

    Annie De Groot, CEO/CSO, EpiVax, Inc.

    clock

    8:30

    Registration & Coffee

    clock

    9:00

    Chairman's Opening Remarks

    Adnan Khan

    Adnan Khan, Senior Scientist Immunology/Pharmacology, UCB

    clock

    9:10

    A computational pipeline for personalised cancer vaccine development

    Annie De Groot

    Annie De Groot, CEO/CSO, EpiVax, Inc.

    • Checkpoint inhibitors are changing cure rates for cancer and generating excitement in the cancer field
    • While cure rates are improving, personalised cancer vaccines may improve cure rates even further
    • Personalised cancer vaccines are feasible using available computational tools
    • Participants will learn how personalised cancer vaccines will move the needle on cancer cures of the future
     

    clock

    9:50

    Integration of immunogenicity risk data to forecast clinical outcomes

    Timothy Hickling

    Timothy Hickling, Immunogenicity Sciences Discipline Lead, Pfizer Pharmaceuticals

    • Immune responses to biologics as a normal response to drug exposure
    • Identifying key risk factors for immunogenicity
    • Working with protein engineers to reduce immunogenicity of biotherapeutics
    • Utilising non-clinical assays for immunogenicity assessment
     

    clock

    10:30

    Morning Coffee

    clock

    11:00

    Influence of Aggregates on in vitro T Cell Responses

    Mark Fogg

    Mark Fogg, Immunology Group Leader, Abzena

    • Immunogenicity of therapeutic protein products can elicit unwanted ADA
    • Protein aggregation can result in enhanced immunogenicity
    • In vitro methods that measure the impact of these aggregates on enhanced immunogenicity will be useful tools in screening processes to avoid or reduce problems associated with ADA
     

    clock

    11:40

    T cell amplification assays for immunogenicity prediction: T cell repertoire and epitopes

    Machteld Tiemessen

    Machteld Tiemessen, Senior Scientist, Janssen

    • Why are T cell assays performed to predict immunogenicity?
    • What kind of data do they produce?
    •  Have they been already confronted to clinical observations?
    • Are they really useful as compared to other predictive approaches?
     

    clock

    12:20

    Networking Lunch

    clock

    13:50

    Correlation of T-cell responses induced by therapeutic cancer vaccines with clinical responses

    Cornelis  Melief

    Cornelis Melief, Chief Scientific Officer, ISA Pharmaceuticals

     

    • In premalignant disease caused by high risk HPV,
    therapeutic vaccination-induced T-cell responses
    correlate with clinical responses
    • In late stage HPV-induced cancer myeloid cell
    depletion by standard chemotherapy fosters robust
    vaccine-induced T cell responses
    • Therapeutic vaccines works as monotherapy in premalignant
    disease, but treatment of late stage cancer
    requires combination of vaccination with immunomodulation

    clock

    14:30

    Afternoon Tea

    clock

    15:00

    Development and validation of cell based antibody neutralisation assays

    Sue Charlton

    Sue Charlton, Scientific Lead, Vaccine Research Group, , Public Health England

    • Examples of validation of cell based neutralisation assays
    • Their application to release / stability testing of vaccines
    • Consideration of the assay life cycle
     

    clock

    15:40

    “Protein aggregates: why do we need to study them? Quantification and characterization of sub-visible particles in protein therapeutics”

    Mantas  Malisauskas

    Mantas Malisauskas, Manager R&D, Baxalta

    • Biopharmaceutical and problems never seen with non-protein substances

    • Protein aggregates structure and function

    • Strategy in analysis and characterization of protein aggregates
     

    clock

    16:20

    Chairman’s Closing Remarks and Close of Day Two

    Adnan Khan

    Adnan Khan, Senior Scientist Immunology/Pharmacology, UCB


    Senior Scientist Immunology/Pharmacology
    UCB
    CEO
    Baliopharm AG
    CEO/CSO
    EpiVax, Inc.
    Postdoctoral Researcher, Cellular and Molecular Immunology
    Free University Of Brussels
    Chief Scientific Officer
    ISA Pharmaceuticals
    Head BioPharma Clinical Immunology
    GSK
    Professor
    University Of Manchester
    Director of Sales
    ProImmune Ltd.
    Associate Director
    Bristol Myers Squibb
    Senior Scientist
    Janssen
    Manager R&D
    Baxalta
    Immunology Group Leader
    Abzena
    Head, Cytokines & Growth Factors, Biotherapeutics Group,
    NIBSC, MHRA
    Director of Biology
    Selecta Biosciences
    Scientific Lead, Vaccine Research Group,
    Public Health England
    Immunogenicity Sciences Discipline Lead
    Pfizer Pharmaceuticals

    Sponsors and Exhibitors

    Official Media Partner

    Official Publication

    Supporters

    Workshops

    Unwanted immunogenicity from bench to bedside
    Workshop

    Unwanted immunogenicity from bench to bedside

    Holiday Inn Kensington Forum
    15 June 2016
    London, United Kingdom

    Interview with UCB

    Download

    Sponsors and Exhibitors


    Abzena

    Sponsors and Exhibitors
    http://www.abzena.com

    Abzena offers a suite of complementary services and technologies. Its range of technologies include immunogenicity assessment, antibody drug conjugation, protein engineering, PEGylation, cell line development , GMP manufacturing and a range of bespoke assays to enables the development of better biopharmaceuticals which will have a greater chance of reaching the market.

    Media Partners


    BioChem Adda

    Official Media Partner
    https://www.biochemadda.com/

    BioChem Adda is a Not-just-for-Profit organization which aims to bring out the most reliable and transparent information about everything related to jobs, careers, education, news, articles, and events from the field of BioSciences and Chemistry!

    Media Partners


    Int. J. of Immunological Studies

    Official Publication
    http://www.inderscience.com/ijis

    IJIS publishes a broad range of papers on all aspects of immunology from scientists in academic and non-academic organisations as well as business and government worldwide. IJIS is the flagship journal of the Frontiers in Immunology Research Network.


    International Journal of Biomedical Engineering and Technology

    Official Publication
    http://www.inderscience.com/ijbet

    IJBET addresses cutting-edge research in the multi-disciplinary area of biomedical engineering and technology. Medical science incorporates scientific/technological advances combining to produce more accurate diagnoses, effective treatments with fewer side effects, and improved ability to prevent disease and provide superior-quality healthcare. A key field here is biomedical engineering/technology, offering a synthesis of physical, chemical, mathematical and computational sciences combined with engineering principles to enhance R&D in biology, medicine, behaviour, and health. IJBET includes the Asia-Pacific Chapter in Biomedical Wireless Technology (APC-BWT).


    Int. J. of Biotechnology

    Official Publication
    http://www.inderscience.com/ijbt

    IJBT provides an international forum and refereed authoritative source of information in the field of Biotechnology and Biotechnics, with emphasis on management and economics, as well as the political and social issues. It aims to disseminate knowledge, provide a learned reference in the field, and establish channels of communication between academic and research experts, policy makers and executives in industry, commerce and investment institutions.


    International Journal of Nano and Biomaterials

    Official Publication
    http://www.inderscience.com/ijnbm

    In recent years, frontiers of research in engineering, science and technology have been driven by developments in nanomaterials, encompassing a diverse range of disciplines such as materials science, biomedical engineering, nanomedicine and biology, manufacturing technology, biotechnology, nanotechnology, and nanoelectronics. IJNBM provides an interdisciplinary vehicle covering these fields. Advanced materials inspired by biological systems and processes are likely to influence the development of novel technologies for a wide variety of applications from vaccines to artificial tissues and organs to quantum computers.

    Media Partners


    Conference Service

    Supporters
    https://www.conference-service.com/

    COMS is a web based system for managing delegate registration, payment, paper submission, review and the book of abstracts. It is a comprehensive and powerful, yet easy to use solution for online conference management including event planning and creation of the detailed agenda.


    Drug Discovery Today

    Supporters
    http://www.drugdiscoverytoday.com/

    Drug Discovery Today covers the whole of the preclinical drug discovery process. The reviews are cutting edge, written by experts in their respective fields and cover all aspects of drug discovery from genomic and proteomic approaches, computational drug design, medicinal chemistry and the translation of these sciences to therapies.


    BioPharm Insight

    Supporters
    http://www.biopharminsight.com

    BioPharm Insight is your definitive guide to the global life sciences community. Subscribers take action on forward-looking intelligence uncovered by an independent team of investigative journalists, and make strategic business decisions using the most comprehensive and powerful real-time database of market analytics and key contacts. Featuring an intuitive online interface and exclusive Active IntelT relational content technology, BioPharm Insight provides an unrivaled capability to segment and analyze the industry with detailed and searchable profiles.


    Swiss Biotech Association

    Supporters
    http://www.swissbiotech.org/

    The Swiss Biotech Association (SBA) is the national industry association for biotechnology, including pharmaceuticals, diagnostics, agriculture, food, cosmetics, environmental biotechnology, and specialty chemicals. Members are companies active in modern biotechnology, such as R&D, Production, Marketing and Sales, Finance, Services and Consulting. SBA provides a networking platform for Life Science clusters, academic and federal institutions the like. Founded in March 1998, the Association grows steadily.


    Technology Networks

    Supporters
    http://go.technologynetworks.com/subscribe-to-newsletters

    Founded in 2000, Technology Networks is established as the leading news provider for life science and drug discovery professionals. In addition, we provide unique content including webcasts, videos, application notes and posters from recent conferences. Our portfolio now includes around 30 focussed scientific communities, all of which are accessible free of charge within TechnologyNetworks.com


    Expert Review of Clinical Immunology

    Supporters
    http://www.tandfonline.com/toc/ierm20/current

    The Expert Review of Clinical Immunology journal (Impact Factor 2.484) provides expert analysis and commentary regarding the performance of new therapeutic and diagnostic modalities in clinical immunology: http://www.tandfonline.com/toc/ierm20/current


    Pharmavision

    Supporters
    http://www.pharmavision.co.uk

    PharmaVision offers a consultancy service providing independent pharmaceutical thematic research to the healthcare industry, the investment community and competitive intelligence specialists. We perform due diligence research and provide expert commentary in healthcare. Our reports combine scientific analysis in drug delivery, R&D technologies and pharmaceutical products including patient modelling, product/technology forecasts and market trends evaluation.


    Select Science

    Supporters
    http://www.selectscience.net/

    SelectScience is an independent, online information resource for the worldwide scientific community, and the home of trusted information for laboratory scientists. Discover impartial, expert opinion and trusted reviews about latest laboratory equipment and techniques; plus videos, application notes and science news from around the world. Become a member for free today.


    Pharmacircle

    Supporters
    http://www.pharmacircle.com

    PharmaCircle is an innovative knowledge management company serving the current and future global leaders in the Pharmaceutical and Biotechnology related industries. PharmaCircle is a one stop information and analysis source for pipeline, products, clinical trials, drug delivery technologies, deals and acquisitions, company financials, venture capital investments, product sales, pharmaceutical services, news, patents and more….

    Holiday Inn Kensington Forum

    97 Cromwell Road
    London SW7 4DN
    United Kingdom

    Holiday Inn Kensington Forum

    Holiday Inn Kensington Forum is perfectly situated in one of London’s most luxurious and beautiful areas within South Kensington. 

    The hotel is just 2 minutes walk from Gloucester Road tube station for convenient travel to Hyde Park, London Eye, Tower Bridge plus more of London’s top attractions. There are also easy and direct links to some major transport hubs including Victoria, Kings Cross St Pancras, Paddington and Heathrow. 

    This distinctive hotel in south London has so much to offer to make all guests really feel at home. The latest Holiday Inn relaunch is not just about the new look and feel for the hotel but to offer guests more benefits during their stay including a pillow menu for extra comfort during their sleep and a curved shower rail for more spacious feel. 

    In addition to our 906 rooms, all business guests can take advantage of our meeting and conference facilities including High Speed Internet Access and unlimited Starbucks coffee at The Academy. Our hotel’s professional event planners are on board to help take the hard work and stress away from planning your next event. 

    So whether you in London on business or pleasure, make the Holiday Inn London Kensington Forum your first choice of hotel and book your accommodation for our lowest internet rate guarantee. 

    HOTEL BOOKING FORM

    Title

    SubTitle
    speaker image

    Content


    Title


    Description

    Download

    Title


    Description

    Download

    Title


    Description


    Download


    WHAT IS CPD?

    CPD stands for Continuing Professional Development’. It is essentially a philosophy, which maintains that in order to be effective, learning should be organised and structured. The most common definition is:

    ‘A commitment to structured skills and knowledge enhancement for Personal or Professional competence’

    CPD is a common requirement of individual membership with professional bodies and Institutes. Increasingly, employers also expect their staff to undertake regular CPD activities.

    Undertaken over a period of time, CPD ensures that educational qualifications do not become obsolete, and allows for best practice and professional standards to be upheld.

    CPD can be undertaken through a variety of learning activities including instructor led training courses, seminars and conferences, e:learning modules or structured reading.

    CPD AND PROFESSIONAL INSTITUTES

    There are approximately 470 institutes in the UK across all industry sectors, with a collective membership of circa 4 million professionals, and they all expect their members to undertake CPD.

    For some institutes undertaking CPD is mandatory e.g. accountancy and law, and linked to a licence to practice, for others it’s obligatory. By ensuring that their members undertake CPD, the professional bodies seek to ensure that professional standards, legislative awareness and ethical practices are maintained.

    CPD Schemes often run over the period of a year and the institutes generally provide online tools for their members to record and reflect on their CPD activities.

    TYPICAL CPD SCHEMES AND RECORDING OF CPD (CPD points and hours)

    Professional bodies and Institutes CPD schemes are either structured as ‘Input’ or ‘Output’ based.

    ‘Input’ based schemes list a precise number of CPD hours that individuals must achieve within a given time period. These schemes can also use different ‘currencies’ such as points, merits, units or credits, where an individual must accumulate the number required. These currencies are usually based on time i.e. 1 CPD point = 1 hour of learning.

    ‘Output’ based schemes are learner centred. They require individuals to set learning goals that align to professional competencies, or personal development objectives. These schemes also list different ways to achieve the learning goals e.g. training courses, seminars or e:learning, which enables an individual to complete their CPD through their preferred mode of learning.

    The majority of Input and Output based schemes actively encourage individuals to seek appropriate CPD activities independently.

    As a formal provider of CPD certified activities, SAE Media Group can provide an indication of the learning benefit gained and the typical completion. However, it is ultimately the responsibility of the delegate to evaluate their learning, and record it correctly in line with their professional body’s or employers requirements.

    GLOBAL CPD

    Increasingly, international and emerging markets are ‘professionalising’ their workforces and looking to the UK to benchmark educational standards. The undertaking of CPD is now increasingly expected of any individual employed within today’s global marketplace.

    CPD Certificates

    We can provide a certificate for all our accredited events. To request a CPD certificate for a conference , workshop, master classes you have attended please email events@saemediagroup.com

    Event Title

    Headline

    Text
    Read More

    I would like to speak at an event

    I would like to attend an event

    I would like to sponsor/exhibit at an event

    SIGN UP OR LOGIN

    Sign up
    Forgotten Password?

    Contact SAE Media Group

    UK Office
    Opening Hours: 9.00 - 17.30 (local time)
    SAE Media Group , Ground Floor, India House, 45 Curlew Street, London, SE1 2ND, United Kingdom
    Tel: +44 (0) 20 7827 6000 Fax: +44 (0) 20 7827 6001
    Website: http://www.smgconferences.com Email: events@saemediagroup.com
    Registered in England - SMi Group Ltd trading as SAE Media Group




    Forgotten Password

    Please enter the email address you registered with. We will email you a new password.

    Thank you for visiting our event

    If you would like to receive further information about our events, please fill out the information below.

    By ticking above you are consenting to receive information by email from SAE Media Group.
    Full details of our privacy policy can be found here https://www.smgconferences.com/privacy-legals/privacy-policy/.
    Should you wish to update your contact preferences at any time you can contact us at data@smgconferences.com.
    Should you wish to be removed from any future mailing lists please click on the following link http://www.smgconferences.com/opt-out

    Fill in your details to download the brochure

    By submitting this form you agree to our privacy policy and consent to receiving communications, you may opt out at any time.