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COPD: Novel Therapeutics and Management Strategies
19 October - 20 October 2015
COPD: Novel Therapeutics and Management Strategies

This event is about the developments made in the field of COPD.
COPD its self-causes 6% of the world’s morbidity. It is predicted that there will be a 30% > increase in the number of cases in the next 10 years.

The disease is chronic and is characterised by a progressive worsening in condition through periods of exacerbation caused by infection and progressive worsening through opportunistic infections.
The disease, though non curable, can be tamed through a range of management mechanisms, such as preventing the development of exacerbations through flu and pneumonia vaccines and early diagnosis and treatment of exacerbations through rapid deployment of antibiotics. Lung function can also be increased and exacerbations reduced through the use of bronchodilators such as corticosteroids and anticholinergic drugs.

 

Now in its 7th year, COPD 2015 will gather a global audience of respiratory experts and scientific pioneers to discuss the latest developments in combinational therapies, new drugs and personalised treatment as well as the challenges of clinical trials. Join us as we ask questions such as: How does one reliably recruit and run clinical trials in a disease that branches to such extremes? What is the correct phenotype to measure in the disease? With the majority of COPD patients on varying courses of polypharmacy due to a range of different debilitating diseases alongside COPD – how can one find a clean patient? Plus much more!

 Our understanding of the pathophysiology in COPD has increased dramatically thanks to developments in the area of network biology. By understanding the complicated mechanisms by which different aspects of the disease interact it is possible to intervene with crucial nodes progressing the disease. Discussions will be opened on the various models of network biology and biomarkers of the disease to gain a greater understanding of this multifaceted disease.

We look forwards to welcoming you to the 7th Annual COPD Conference 2015 taking place in central London on the 19th-20th October 2015.

 

FEATURED SPEAKERS

Frank Thielmann

Frank Thielmann

Operational Lead, Inhalation New Solids, Novartis Pharma AG
Konstantinos Kostikas

Konstantinos Kostikas

Medical Director Respiratory COPD Region Europe, Novartis Pharma
Matthew Sleeman

Matthew Sleeman

Senior Director of Biology, Respiratory, Inflammation and Autoimmunity, MedImmune
Philip  Silkoff

Philip Silkoff

Senior Medical Director, Johnson and Johnson Pharmaceutical Services LLC
Sanjeeva Dissanayake

Sanjeeva Dissanayake

Head of Medical Sciences – Respiratory, Mundipharma

Antonio Gomez-Munoz

Professor of Biochemistry and Molecular Biology, University of the Basque Country
Antonio Gomez-Munoz

Brian Leaker

Medical Director at Respiratory Clinical Trials, The Heart Lung Centre
Brian Leaker

Chetna Bhatia

Respiratory Therapist & Research , HUG
Chetna  Bhatia

Ewan Walters

Medical Director, Teva UK Ltd
Ewan Walters

Frank Thielmann

Operational Lead, Inhalation New Solids, Novartis Pharma AG
Frank Thielmann

Geoff Down

Medical Director, Respiratory Portfolio, Circassia Ltd
Geoff Down

Graham Clarke

Head of Respiratory Phase I, Quintlies Ltd.
Graham Clarke

Jan-Anders Karlsson

CEO , Verona Pharma
Jan-Anders Karlsson

John Hurst

Senior Clinical Lecturer, Honorary Consultant, University College London
John Hurst

Juan Gispert

Senior Medical Director and Chair Centre of Excellence, Quintiles
Juan Gispert

Kevin Stirzaker

Head of Security and Compliance, Truphone
Kevin Stirzaker

Konstantinos Kostikas

Medical Director Respiratory COPD Region Europe, Novartis Pharma
Konstantinos Kostikas

Dr Konstantinos Kostikas, MD, PhD, FCCP
Regional Medical Director Respiratory, Region Europe, Novartis Pharma

I am a Pulmonologist trained in the University of Athens Medical School and the Royal Brompton Hospital, UK. I practiced Respiratory Medicine since 2004 in Academic (University of Thessaly and Atehns Medical Schools, Greece) and private practice settings. I was involved in several posts of the European Respiratory Society (ERS), including the role of Learning Resources Director. My research activities focus on asthma and COPD (biomarkers, phenotyping, comorbidities and exacerbations). I have 110 publications in PubMed since 2002 and several contributions to medical textbooks. I am since January 2015 the Regional Medical Director Respiratory (COPD) Region Europe, Novartis Pharma.
 

Matthew Sleeman

Senior Director of Biology, Respiratory, Inflammation and Autoimmunity, MedImmune
Matthew Sleeman

Noel Snell

Director of Research , British Lung Foundation
Noel  Snell

Pankaj Bhavsar

Research Lecturer, Imperial College London
Pankaj Bhavsar

Paul Lewis

Chief Scientific Officer, Glyconics
Paul Lewis

Philip Silkoff

Senior Medical Director, Johnson and Johnson Pharmaceutical Services LLC
Philip  Silkoff

Sanjeeva Dissanayake

Head of Medical Sciences – Respiratory, Mundipharma
Sanjeeva Dissanayake

Stefano Petruzzelli

Chief Medical Officer and Director Global Clinical Development, Chiesi Farmaceutici S. P. A.
Stefano Petruzzelli

 

sponsors

Conference agenda

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8:30

Registration & Coffee

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9:00

Opening remarks and introductions

Graham Clarke

Graham Clarke, Head of Respiratory Phase I, Quintlies Ltd.

Juan Gispert

Juan Gispert, Senior Medical Director and Chair Centre of Excellence, Quintiles

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9:15

Session 1: Smarter approaches in early clinical development in COPD

• Adaptive designs and POC studies in COPD
• Incorporation of challenge models to determine POM – LPS and Ozone Challenge
• Functional markers of COPD in adaptive designs
• Sputum methodologies to enhance key Biomarkers in COPD

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10:00

Coffee

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10:15

Session 2: Full development of COPD compounds

• Regulatory perspective
• Current landscape of compounds under development
• Real world data as strategy driver
 

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11:00

Coffee

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11:15

Session 3: Maximizing efficiency of COPD trials

• Recruitment strategies to ensure proper study completion
• Patient centric studies
• Compliance in long term studies
 

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12:00

End of workshop

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8:30

Registration & Coffee

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9:00

Chairman's Opening Remarks

Frank Thielmann

Frank Thielmann, Operational Lead, Inhalation New Solids, Novartis Pharma AG

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9:10

From molecule to medicine - formulation development and manufacturing of dry powder inhalation products

Frank Thielmann

Frank Thielmann, Operational Lead, Inhalation New Solids, Novartis Pharma AG

•          Device and formulation systems and their selection
•          Properties of drug substance and product and impact on in-vitro/ vivo performance  
•          Challenges in the manufacturing of DPI systems
•          Future trends in inhaled drug delivery
 

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9:50

Optimising treatment for COPD – new strategies for combination therapy

Ewan Walters

Ewan Walters, Medical Director, Teva UK Ltd

• Are therapies that provide bronchodilation useful in COPD?
• Pros and cons of combination therapies
• Role of real Life Data
• Change in management strategies in UK    

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10:30

Morning Coffee

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11:00

Triple fixed dose combination therapy in COPD

Geoff Down

Geoff Down, Medical Director, Respiratory Portfolio, Circassia Ltd

• Therapeutic rationale
• Development challenges
• Potential future options
 

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11:40

p38 mitogen-activated protein kinase pathways in asthma and COPD

Pankaj Bhavsar

Pankaj Bhavsar, Research Lecturer, Imperial College London

  • Patients with severe asthma or COPD are resistant to the beneficial therapeutics effects of corticosteroid therapy
  • Heightened p38 MAPK activity is observed in alveolar macrophages (AM), peripheral blood mononuclear cells (PBMC) and airway smooth muscle cells of severe asthma and COPD, and is associated with impaired steroid suppression of cytokine release 
  • A p38 MAPK inhibitor and dexamethasone synergistically suppress induced cytokine release in AM and PBMC of severe asthma or COPD  
  • p38 MAPK inhibitors provide a potential new therapy for the treatment of severe asthma or COPD where reversibility of corticosteroid insensitivity could lead to better control of disease symptoms.
     
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    12:10

    Networking Lunch

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    13:30

    Ceramide 1-phosphate, a novel therapeutic agent for treatment of COPD

    Antonio Gomez-Munoz

    Antonio Gomez-Munoz, Professor of Biochemistry and Molecular Biology, University of the Basque Country

    • Ceramide 1-phosphate (C1P) reduces lung inflammation
    • C1P stimulates cell growth, inhibits apoptosis, and promotes cell migration
    • The mechanisms by which C1P blocks inflammatory responses involve inhibition of sphingomyelinase and serine palmitoyl transferase activities, reduction of pro-inflammatory cytokines, and inhibition of NF-kB expression.
     

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    14:10

    Asthma-Chronic obstructive pulmonary disease Overlap Syndrome: ACOS or C(H)AOS?

    Konstantinos Kostikas, Medical Director Respiratory COPD Region Europe, Novartis Pharma

  • Definition and characteristics of a grey-zone syndrome, excluded from current asthma and COPD trials
  • Applying current knowledge to clinical practice
  • Unmet needs and the future of ACOS
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    14:50

    Afternoon Tea

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    15:20

    Developing clinical trials in pulmonary rehabilitation

    Chetna  Bhatia

    Chetna Bhatia, Respiratory Therapist & Research , HUG

    • Patient selection and recruitment
    • Designing an effective rehabilitation programme
    • Overcoming recruitment and adherence hurdles
    • Prospects in the field
     

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    16:10

    Asthma–chronic obstructive pulmonary disease (COPD) overlap syndrome (ACOS)

    Brian Leaker

    Brian Leaker, Medical Director at Respiratory Clinical Trials, The Heart Lung Centre

    • Incidence of ACOS
    • Clinical trials have consistently ignored this condition, as evidenced by strict inclusion and exclusion criteria that exclude either asthma patients from COPD studies or COPD patients from asthma studies, how this is changing in drug development programmes
    • Explaining the phenotype
    • Review of potential pharmacotherapeutic approaches
     

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    16:50

    Chairmans Closing Remarks and Close of Day One

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    8:30

    Registration & Coffee

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    9:00

    Chairman's Opening Remarks

    Stefano Petruzzelli

    Stefano Petruzzelli, Chief Medical Officer and Director Global Clinical Development, Chiesi Farmaceutici S. P. A.

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    9:10

    Analysis of COPD biomarkers in sputum at the point-of-care

    Paul Lewis

    Paul Lewis, Chief Scientific Officer, Glyconics

    • Use of infra-red spectroscopy in respiratory clinical diagnostics
    • Determination of sputum biomarkers for COPD and exacerbation
    • Development of a simple hand-held device for biomarker detection
    • Determination of sensitivity and specificity to predict exacerbation using device and biomarkers
    • Evaluation of device in the SPEDIC clinical trial
    • Potential for use of device in primary care to aid COPD management

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    9:50

    Investigating the role of ectopic lymphoid follicles in respiratory disease

    Matthew Sleeman

    Matthew Sleeman, Senior Director of Biology, Respiratory, Inflammation and Autoimmunity, MedImmune

    • Exploring the role of lung damage and injury in formation of ectopic follicles
    • Evaluation of follicle formation in models of COPD
    • Review the key pathways and mechanisms that contribute to lymphoid follicle formation in COPD and related interstitial lung diseases
     

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    10:30

    Morning Coffee

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    11:00

    Endpoints in COPD trials

    Sanjeeva Dissanayake

    Sanjeeva Dissanayake, Head of Medical Sciences – Respiratory, Mundipharma

    • An overview of endpoints used in COPD trials: pitfalls, limiting risk, and extracting additional value
    • A focus on phase 3 registration studies

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    11:40

    Understanding COPD and comorbidities

    John Hurst

    John Hurst, Senior Clinical Lecturer, Honorary Consultant, University College London

    • What is the link between comorbidities and disease
    • Current issues with treatments for COPD
    • The use of corticosteroids, do they cause more harm than good?
     

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    12:20

    Networking Lunch

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    13:20

    The ADEPT study "Airways Disease Endotyping for Personalised Therapeutics": Study design, populations and initial learnings

    Philip Silkoff

    Philip Silkoff, Senior Medical Director, Centocor

  • COPD is a heterogeneous disease; surprised?
  •  When assessing biomarkers in COPD, there may be profound impacts of current smoking and also inhaled steroid use.
  •  A deeper level of disease understanding may assist in discovering novel therapies for COPD based on a personalized medicine approach
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    14:00

    Update on the clinical management of exacerbations

    Stefano Petruzzelli

    Stefano Petruzzelli, Chief Medical Officer and Director Global Clinical Development, Chiesi Farmaceutici S. P. A.

    • The course of COPD exacerbations. What are we measuring?
    • Similarities and differences between healthcare resource utilisation definition and EXACT
    • How do exacerbations relate to a range of health outcomes
     

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    14:40

    Afternoon Tea

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    15:10

    A Patients Lifecycle

    Kevin Stirzaker

    Kevin Stirzaker, Head of Security and Compliance, Truphone

  • Denial - Of course I haven't got COPD
  • Acceptance - OK, so I do have COPD
  • Deal with it - No getting away from COPD
  • Realisation - The future with COPD

  •  

     

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    15:40

    Respiratory research in the UK - the role of the British Lung Foundation

    Noel  Snell

    Noel Snell, Director of Research , British Lung Foundation

    • The current state of UK respiratory research: why is it grossly underfunded compared with therapeutic areas of similar disease burden?
    • Development of a revised research strategy for the BLF in partnership with patients
    • What is the future outlook for respiratory research in the UK?
     

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    16:20

    Chairman’s Closing Remarks and Close of Day Two


    Professor of Biochemistry and Molecular Biology
    University of the Basque Country
    Medical Director at Respiratory Clinical Trials
    The Heart Lung Centre
    Respiratory Therapist & Research
    HUG
    Medical Director
    Teva UK Ltd
    Operational Lead, Inhalation New Solids
    Novartis Pharma AG
    Medical Director, Respiratory Portfolio
    Circassia Ltd
    Head of Respiratory Phase I
    Quintlies Ltd.
    CEO
    Verona Pharma
    Senior Clinical Lecturer, Honorary Consultant
    University College London
    Senior Medical Director and Chair Centre of Excellence
    Quintiles
    Head of Security and Compliance
    Truphone
    Medical Director Respiratory COPD Region Europe
    Novartis Pharma
    Senior Director of Biology, Respiratory, Inflammation and Autoimmunity
    MedImmune
    Director of Research
    British Lung Foundation
    Research Lecturer
    Imperial College London
    Chief Scientific Officer
    Glyconics
    Senior Medical Director
    Johnson and Johnson Pharmaceutical Services LLC
    Head of Medical Sciences – Respiratory
    Mundipharma
    Chief Medical Officer and Director Global Clinical Development
    Chiesi Farmaceutici S. P. A.

    Sponsors and Exhibitors

    Official Media Partner

    Supporters

    Workshops

    Improving probability of success in COPD drug development

    Improving probability of success in COPD drug development

    Holiday Inn Regents Park
    21 October 2015
    London, United Kingdom

    An Interview with Quintiles

    Download

    COPD 2015 Attendee List

    Download

    An interview with Chetna Bhatia, Physical Therapist at University Hospital Geneva

    Download

    Sponsors and Exhibitors


    Medicines Evaluation Unit

    Sponsors and Exhibitors
    http://www.meu.org.uk

    The Medicines Evaluation Unit is one of the UKs leading contract research organisations, possessing extensive pharmaceutical, scientific and clinical expertise, allied with fast volunteer recruitment within a state of the art hospital-based research facility, enabling MEU to offer clients positive clinical trials solutions. The MEUs core skill area is in respiratory clinical trials, together with early phase exploratory studies, enhanced by the specialist support offered by collaboration with the University Hospital of South Manchester NHS Trust, and its extensive facilities. The MEU has also undergone favourable inspections by the MHRA, and holds MHRA phase 1 accreditation, together with an MHRA MIA (IMP) licence to perform assembly activities.


    Quintiles

    Sponsors and Exhibitors
    http://www.quintiles.com

    Quintiles Transnational (NYSE: Q), is a Fortune 500 company and the world’s largest provider of biopharmaceutical development and commercial outsourcing services with a network of more than 32,000 employees conducting business in approximately 100 countries.

    Media Partners


    BioMed Central - COPD Research and Practice

    Official Media Partner
    http://www.copdrp.com/

    BioMed Central is an online STM publisher of more than 270 peer-reviewed open access journals. The portfolio of journals spans all areas of biology, biomedicine and medicine, with many journals publishing content related to pulmonary medicine and allergy research. Examples of such journals include: COPD Research and Practice, Multidisciplinary Respiratory Medicine, Respiratory Research, and Allergy, Asthma & Clinical Immunology. All original research articles published by BioMed Central are made freely accessible online immediately upon publication. Authors publishing with BioMed Central retain copyright of their work, licensing it under the Creative Commons Attribution License which allows articles to be re-used and re-distributed without restriction, as long as the original work is correctly cited. BioMed Central is owned by Springer Science+Business Media, and also hosts the SpringerOpen platform.


    BMC Pulmonary Medicine

    Official Media Partner
    http://www.biomedcentral.com/bmcpulmmed

    An open access, peer-reviewed journal that considers articles on all aspects of the prevention, diagnosis and management of pulmonary and associated disorders, as well as related molecular genetics, pathophysiology, and epidemiology.


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    http://ondrugdelivery.com

    ONdrugDelivery provides 30,000 readers throughout global pharma/biopharma, with the latest, most pertinent industry information and intelligence about the drug delivery-related ideas, technologies, services and products the sector is developing. Established in 2004, and trusted throughout the industry for its high quality contributions from leading drug delivery experts, ONdrugDelivery is a must for pharma / biotech industry professionals who need to know what’s going on in drug delivery. Subscribe online today to the print or free digital edition: www.ondrugdelivery.com/subscribe.


    COPD: Journal of Chronic Obstructive Pulmonary Disease

    Official Media Partner
    http://www.tandfonline.com/icop20

    COPD: Journal of Chronic Obstructive Pulmonary Disease publishes advances in the pathophysiology, diagnosis, management, and control of lung and airway disease and inflammation - providing a unique forum for the discussion, design, and evaluation of more efficient and effective strategies in patient care.


    Respiratory Research

    Official Media Partner
    http://www.respiratory-research.com/

    The leading open access respiratory journal, with an Impact Factor of 3.36 and monthly accesses of over 150,000. Publishing on all areas of basic and clinical respiratory medicine, including asthma and COPD.

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    PharmaVision offers a consultancy service providing independent pharmaceutical thematic research to the healthcare industry, the investment community and competitive intelligence specialists. We perform due diligence research and provide expert commentary in healthcare. Our reports combine scientific analysis in drug delivery, R&D technologies and pharmaceutical products including patient modelling, product/technology forecasts and market trends evaluation.


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    Inderscience is a dynamic, leading, independent journal publisher. The company disseminates the latest research across the broad fields of science, engineering and technology; management, public and business administration; environment, ecological economics and sustainable development; computing, ICT and internet/web services, and related areas. Inderscience offers over 35 years' experience in publishing and has succeeded in building a substantial collection approaching 400 high-quality peer-reviewed international research journals in both online and print formats. We offer a variety of ways to keep up-to-date with the latest published leading-edge research while our online collection represents a fully-searchable digital archive of around 60,000 articles.


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    Pharmalicensing (www.pharmalicensing.com) is the premier biopharmaceutical Open Innovation resource designed for professionals involved with partnering, licensing and business development worldwide. Actively supporting all forms of partnering and in- and out-licensing activities, Pharmalicensing utilizes the unique online Showcase Profiling & Discover services, as well as its renowned Partnering Search service leveraging its global network of industry experts, to enable companies to identify and engage with appropriate partners around the world. Pharmalicensing is actively utilized by many tens of thousands of industry professionals each month. Pharmalicensing is a division of Cognis Group, Inc.


    Int. J. of Biotechnology

    Supporters
    http://www.inderscience.com/ijbt

    IJBT provides an international forum and refereed authoritative source of information in the field of Biotechnology and Biotechnics, with emphasis on management and economics, as well as the political and social issues. It aims to disseminate knowledge, provide a learned reference in the field, and establish channels of communication between academic and research experts, policy makers and executives in industry, commerce and investment institutions.

    Holiday Inn Regents Park

    Carburton Street
    London W1W 5EE
    United Kingdom

    Holiday Inn Regents Park

    Choose the well-connected Holiday Inn London-Regent's Park hotel, with a superb central London location and speedy transport links. Holiday Inn London-Regent's Park is in a leafy and cosmopolitan area of central London, a 10-minute walk from bustling Oxford Street. Leave your car in our NCP managed underground car park, and explore London by Tube. Great Portland Street Tube station is 25 metres from the hotel, from where you can reach the City and Canary Wharf in 30 minutes, and London Heathrow Airport in 45 minutes.

    Wireless Internet is available throughout the hotel, and you can invite up to 300 people to events at the Academy Conference Centre, with an IT technician and break-out zones. Holiday Inn London-Regent's Park is a 10-minute walk from Santander's offices and businesses in the BT Tower. Stroll 5 minutes to Regent's Park, where you'll find London Zoo and pretty Primrose Hill. We're a 10-minute walk from Bond Street boutiques and 20 minutes from Buckingham Palace and cruises on the River Thames.

    Ask our Concierge to plan your day out and book West End theatre tickets. Room Service is available 24 hours at Holiday Inn London-Regent's Park, or dine in the vibrant Junction Restaurant. Our Junction Bar has a menu of light bites, and a hot breakfast buffet is served daily.

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    WHAT IS CPD?

    CPD stands for Continuing Professional Development’. It is essentially a philosophy, which maintains that in order to be effective, learning should be organised and structured. The most common definition is:

    ‘A commitment to structured skills and knowledge enhancement for Personal or Professional competence’

    CPD is a common requirement of individual membership with professional bodies and Institutes. Increasingly, employers also expect their staff to undertake regular CPD activities.

    Undertaken over a period of time, CPD ensures that educational qualifications do not become obsolete, and allows for best practice and professional standards to be upheld.

    CPD can be undertaken through a variety of learning activities including instructor led training courses, seminars and conferences, e:learning modules or structured reading.

    CPD AND PROFESSIONAL INSTITUTES

    There are approximately 470 institutes in the UK across all industry sectors, with a collective membership of circa 4 million professionals, and they all expect their members to undertake CPD.

    For some institutes undertaking CPD is mandatory e.g. accountancy and law, and linked to a licence to practice, for others it’s obligatory. By ensuring that their members undertake CPD, the professional bodies seek to ensure that professional standards, legislative awareness and ethical practices are maintained.

    CPD Schemes often run over the period of a year and the institutes generally provide online tools for their members to record and reflect on their CPD activities.

    TYPICAL CPD SCHEMES AND RECORDING OF CPD (CPD points and hours)

    Professional bodies and Institutes CPD schemes are either structured as ‘Input’ or ‘Output’ based.

    ‘Input’ based schemes list a precise number of CPD hours that individuals must achieve within a given time period. These schemes can also use different ‘currencies’ such as points, merits, units or credits, where an individual must accumulate the number required. These currencies are usually based on time i.e. 1 CPD point = 1 hour of learning.

    ‘Output’ based schemes are learner centred. They require individuals to set learning goals that align to professional competencies, or personal development objectives. These schemes also list different ways to achieve the learning goals e.g. training courses, seminars or e:learning, which enables an individual to complete their CPD through their preferred mode of learning.

    The majority of Input and Output based schemes actively encourage individuals to seek appropriate CPD activities independently.

    As a formal provider of CPD certified activities, SAE Media Group can provide an indication of the learning benefit gained and the typical completion. However, it is ultimately the responsibility of the delegate to evaluate their learning, and record it correctly in line with their professional body’s or employers requirements.

    GLOBAL CPD

    Increasingly, international and emerging markets are ‘professionalising’ their workforces and looking to the UK to benchmark educational standards. The undertaking of CPD is now increasingly expected of any individual employed within today’s global marketplace.

    CPD Certificates

    We can provide a certificate for all our accredited events. To request a CPD certificate for a conference , workshop, master classes you have attended please email events@saemediagroup.com

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    Contact SAE Media Group

    UK Office
    Opening Hours: 9.00 - 17.30 (local time)
    SAE Media Group , Ground Floor, India House, 45 Curlew Street, London, SE1 2ND, United Kingdom
    Tel: +44 (0) 20 7827 6000 Fax: +44 (0) 20 7827 6001
    Website: http://www.smgconferences.com Email: events@saemediagroup.com
    Registered in England - SMi Group Ltd trading as SAE Media Group




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