Analgesics are among the most commonly prescribed drugs in the world and yet, finding novel targets and mechanisms that may elevate hard to treat pain is becoming more difficult.
After nearly 20 years of successful Pain Therapeutics conferences, join us for the 18th Annual Pain Therapeutics conference in May to explore novel targets for pain therapeutics, new translational approaches and pipeline drug development from the leading pharma companies in pain management.


With more case studies, improved networking opportunities and presentations on exciting cutting edge research, the 18th Annual Pain Therapeutics conference will equip you with the latest knowledge to advance your research and trials.

Exclusive content from industry leaders - follow Download Centre tab to view insightful interviews with Lotus Clinical Research and Centrexion Therapeutics

The upcoming Pain Therapeutics conference moves away from well discussed topics such as opioid dependence and animal models and focuses on the most exciting current research, opinions, novel targets and mechanisms and advances in the field of analgesic medicine

  • Discover the novel targets for pain management and hear how leading pharma companies are utilising them to elevate pain across a range of pain types.
  • Learn from exciting case studies of analgesic drug development and trials.
  • Explore the mechanisms by which that latest drugs elevate pain.
  • Discuss the future of pain therapeutics and how big data and technology are shaping the industry..
  • Advance your research and trials with the latest advice from the regulatory bodies
  • Hear industry perspectives from leading pharamceutical companies 

View full list of topics in the event programme - follow Download Centre tab


Who Should attend:

Chief Executive Officer, Chief Scientific Officers, Chief Medical Officers, Managing Directors, CEO, Head of Department, Principal Research Scientists, Clinical lead, Clinical Operations in the following fields:

  • Pain and Migraine
  • Inflammation
  • Chronic Pain
  • Neuropathic Pain
  • Analgesic pre-clinical development
  • Anaesthesia and Pain Management
  • CNS clinical trials
  • Ion Channel Pharmacology
  • Pharmacology Intelligence
  • Translational science
  • Drug development
  • Exploratory development


Past Attendees include:

AiCure; Amgen; Analgesia Partnership; Apollo Therapeutics; AstraZeneca; Bayer; Bayer AG; biogen; Cara Therapeutics ; Centre for Human Drug Research; Centrexion Therapeutics Corp.; Chdr; Clermont Universit; Convergence Pharmaceuticals; Daiichi Sankyo Co. Ltd.; Daiichi Sankyo co.ltd; Eli Lilly and Company; ENSCCF Sigma Clermont; Eupraxia Pharmaceuticals Inc; Family Cottage Sydney; GlaxoSmithKline; Grunenthal; Grunenthal GmbH; Gsk; Innopain; Ipsen Innovation; J & JPRD; Kings College London; Lucideon; MD Biosciences; Merck & Co.; MRC Technology; Mundipharma International Limited; Mundipharma International Ltd; Mundipharma Research; Mundipharma Research GmbH & Co. KG; Mundipharma Research Ltd; Nektar Therapeutics; NeuroDigm; Novartis; Pharmaleads; Premier Research; Queens University Belfast; Queen's University Belfast; Transpharmation Ltd; University of Manchester; US Army Institute for Surgical Research; Zoetis;

Conference agenda



Registration & Coffee



Chairman's Opening Remarks

William Schmidt, Vice President, Clinical Development , ViroMed



Finding targets and using animal models appropriately for pain therapeutics

Lisa Broad, Senior Research Advisor , Eli Lilly and Company

  • Translatability of preclinical evidence is debated in the pain field, but are there exceptions that prove (or disprove) the rule?
  • Alternatively, can we take an opportunistic approach and focus on targets with clinical evidence provided by serendipity?
  • This presentation will address these questions considering various examples.



    Drug discovery approaches in neuropathic pain and migraine – apples and oranges or lemons and limes?

    Gordon Munro, Senior Scientist, Danish Headache Centre

  • Therapeutics target distinct facets of disease pathophysiology in neuropathic pain and migraine
  • Shared neurobiological mechanisms in neuropathic pain and migraine
  • Limitations to drug development –animal models and/or patient populations
  • Harmonizing knowledge gained from neuropathic pain research and development with migraine drug discovery
  • clock


    Morning Coffee



    Dissociation of Responses to Heat and Mechanical Stimuli in a Rodent Model of Rett Syndrome

    Sigal Meilin, Chief Scientific Officer, MD Biosciences



    Second Networking Break



    KEYNOTE ADDRESS: Abdominoplasty as a Novel Analgesic Model for Acute Soft Tissue Pain

    Neil Singla, Founder & Chief Scientific Officer, Lotus Clinical Research, Llc



    Networking Lunch



    Updates on the Therapeutic Application of Botulinum Neurotoxin in Pain: A pre-clinical approach

    Mikhail Kalinichev, Director, in vivo Neurology, Ipsen

    •  While the therapeutic application of botulinum neurotoxin in pain field has grown rapidly during the last decades, the growth has been led primarily by observations and studies performed in the clinic 
    •  Testing botulinum neurotoxin in pre-clinical models of pain can provide an opportunity for systematic evaluation of treatment variables and subsequent improvements in clinical study design
    • Pre-clinical experiments can also help further our understanding of the mechanisms mediating therapeutic efficacy of neurotoxin in pain and in designing a range of modified neurotoxin molecules with enhanced therapeutic profiles


    VM202, a DNA-based Potential Disease-Modifying Treatment for Painful Diabetic Neuropathy

    William Schmidt, Vice President, Clinical Development , ViroMed

  • VM202 is a naked plasmid DNA vector engineered to express two isoforms of human hepatocyte growth factor (HGF).
  • In an ongoing Phase 3 clinical study, VM202 (8 mg/leg) or Placebo is administered i.m. to the calf muscle of each leg in a defined multi-injection pattern on Days 0 and 14 and again on Days 90 and 104.
  • Phase I/II and separate Phase 2 results show robust reductions in foot pain (p<0.05 vs. baseline) and a trend in improved sensory function through 9-12 months after initial treatment in subjects receiving VM202.
  • Pain relieving effects were more pronounced in patients who are not taking Lyrica (pregabalin) and/or Neurontin (gabapentin).
  • VM202 demonstrated an excellent safety profile in Phase I/II and Phase 2 clinical studies.
  • clock


    Zilretta: Development of an extended release intra-articular therapeutic for osteoarthritis

    Becca Senter, Principal Scientist, Pharmacology, Flexion Therapeutics

  • Zilretta microsphere technology – how does it work?
  • The challenges of developing an extended release product
  • Summary of pre-clinical data
  • Summary of clinical studies
  • Case study examples
  • clock


    Afternoon Tea



    Trial conduct in chronic pain conditions; Pitfalls and challenges

    Yanina Flossbach

    Yanina Flossbach, Associate Medical Director Neuroscience , Novartis Pharmaceuticals

  • Patient reported outcomes in clinical trials in pain
  • Reducing placebo responses
  • Patient recruitment challenges 
  • Data handling and management
  • Other considerations
  • clock


    Chairman’s Closing Remarks and Close of Day One

    William Schmidt, Vice President, Clinical Development , ViroMed



    Registration & Coffee



    Co-chairs' Opening Remarks

    Randall Stevens, Chief Medical Officer, Centrexion Therapeutics Corp.

    Kerrie Brady, Chief Business Officer, Executive VP Strategy, Centrexion Therapeutics Corp.



    The TREK 1 agonists, a promising way to solve the opioid crisis?

    Denis Ardid, Head of the Pharmacology Department , Clermont Universit

  • An exemple of TREK 1 agonists: the substituted acrilyc acid derivatives
  • In vitro and in vivo pharmacological profile
  • Challenges and promises for the future
  • clock


    CNTX-6970 a novel CCR2 antagonist with a unique analgesic signature

    Randall Stevens, Chief Medical Officer, Centrexion Therapeutics Corp.

  • Mechanism of action
  • Unique analgesic signature in preclinical models
  • Using Big Data to identify clinical development targets
  • Findings from Phase 1 clinical studies and next steps
  • clock


    Morning Coffee



    Selective TARP-dependent AMPA Receptor Antagonists as a Novel Therapy for Chronic Pain

    Eric Nisenbaum, Head of Neurophysiology, Eli Lilly & Co

  • The role of AMPA receptors in synaptic plasticity in pain pathways
  • Expression and functional consequences of Transmembrane AMPA receptor Regulatory Proteins (TARPs)
  • Identification of TARP-dependent AMPA receptor antagonists
  • Evidence for LY3130481 (CERC-611) as a novel analgesic
  • clock


    Drugging the un-druggable: P2X4 mAbs as therapeutics for pain

    Iain Chessell, VP & Head, IMED Neuroscience , AstraZeneca

  • Novel approaches to discovery of antibodies to P2X4
  • Functional and electrophysiological characterisation
  • Reaching the CNS – application of novel BBB technologies to access the spinal cord with antibody therapies
  • Efficacy in preclinical models and next steps
  • clock


    Round table discussion session

  • Why do we fall short in demonstrating the efficacy of novel therapeutic compounds in the lab?
    Iain Chessell


  • Opioid drugs – Amid an opioid crisis, do abuse resistant drugs work and are we doing enough to reduce harm from opioids?
    Joseph Stauffer


  • How should patient engagement be managed clinical trials for analgesic drugs to reduce the placebo effect and increase the success of clinical trials?
    Randall Stevens


  • What can the pain therapeutics industry expect with the ageing population?
    Kerrie Brady


  • Why are novel analgesic targets so challenging to find and target effectively with drugs?
    Jenny Laird


  • Can stem cells ever replace animal models in preclinical studies? – Benefits and challenges.
    Theo Meert


  • Kerrie Brady, Chief Business Officer, Executive VP Strategy, Centrexion Therapeutics Corp.

    Iain Chessell, VP & Head, IMED Neuroscience , AstraZeneca

    Randall Stevens, Chief Medical Officer, Centrexion Therapeutics Corp.



    Networking Lunch



    Big Data for Big Decisions

    Kerrie Brady, Chief Business Officer, Executive VP Strategy, Centrexion Therapeutics Corp.

  • How to best develop a portfolio of novel non-opioid products for pain?
  • Integration of human expertise and artificial intelligence
  • Using metadata to qualify big data output
  • Can Big Data increase technical success for novel pain drug development?
  • clock


    Development update on Erenumab

    Daniel Mikol, Executive Medicl Director Global Development Neuroscience, Amgen

  • The calcitonin gene-related peptide  (CGRP) pathway is pathophysiologically relevant in migraine
  • Erenumab is an investigational monoclonal antibody targeting the canonical receptor for CGRP
  • In episodic migraine prevention studies, erenumab has demonstrated efficacy in reducing migraine frequency and use of acute headache medications
  • In chronic migraine, erenumab has demonstrated efficacy in reducing migraine frequency and use of acute medications in patients with or without acute medication overuse
  • clock


    Afternoon Tea



    An industry perspective from Grunenthal

    Mark Field

    Mark Field, Senior Vice President, Head Innovation Unit Pain, Grunenthal GmbH



    Co-chairs' Closing Remarks and Close of Day Two



    End of day networking session

    Principal Scientist, Pharmacology
    Flexion Therapeutics
    Executive Medicl Director Global Development Neuroscience
    Head of the Pharmacology Department
    Clermont Universit
    Head of Neurophysiology
    Eli Lilly & Co
    Senior Scientist
    Danish Headache Centre
    VP & Head, IMED Neuroscience
    Scientific Director
    Chief Business Officer, Executive VP Strategy
    Centrexion Therapeutics Corp.
    Senior Research Advisor
    Eli Lilly and Company
    Senior Vice President, Head Innovation Unit Pain
    Grunenthal GmbH
    Founder & CEO
    Metys Pharmaceuticals
    Director, in vivo Neurology
    Founder & Chief Scientific Officer
    Lotus Clinical Research, Llc
    Chief Medical Officer
    Centrexion Therapeutics Corp.
    Chief Scientific Officer
    MD Biosciences
    Vice President, Clinical Development
    Associate Medical Director Neuroscience
    Novartis Pharmaceuticals

    Sponsors and Exhibitors

    Official Media Partner

    Official Publication

    Online Partner



    [Interview] - W. Schmidt, ViroMed


    [Attendee list] - Pain Therapeutics 2018


    [Programme] - Main Conference


    [Speaker Line-up]


    [Workshop B] - Programme


    [Workshop A] - Programme


    [Interview] - Randall Stevens, Centrexion Therapeutics


    [Interview] - Kerrie Brady, Centrexion Therapeutics


    [Interview] - Lotus Clinical Research


    [Infographics] - Pain Therapeutics Conference




    Sponsors and Exhibitors

    Lotus Clinical Research

    Sponsors and Exhibitors

    Lotus Clinical Research is a specialty analgesic CRO, research site, and regulatory consulting firm supporting all phases of discovery for analgesic treatments, focused on improving the scientific accuracy of analgesic programs. Led by Dr. Neil Singla, Lotus focuses on optimizing design/conduct of clinical trials in pain, providing scientific leadership at every step of the development process.

    MD Biosciences

    Sponsors and Exhibitors

    MD Biosciences Neuro is a preclinical and translational contract research organization (CRO) offering services for drug development in the field of neurology and pain research. We understand that finding a trust-worthy preclinical partner is a top priority for drug developers and believe that you should have confidence in the partner you choose. That's why we are dedicated to providing each client valued expertise and advice, experience for flawless execution, and flexibility to meet the needs of rapidly changing requirements.

    With a presence in the innovation hubs of Cambridge, Massachusetts and with state of the art laboratories in Israel, our team is dedicated to building collaborative programs and creating lasting partnerships in the biotechnology community.

    Premier Research

    Sponsors and Exhibitors

    Premier Research is a leading clinical development service provider that helps highly innovative biotech, specialty pharma, and medical device companies transform breakthrough ideas into reality. The company has a wealth of experience in the execution of global, regional and local clinical development programs with a special focus on addressing unmet needs in areas such as analgesia, dermatology, medical device, neuroscience, oncology, pediatrics, and rare disease. Premier Research operates in 84 countries and employs 1,100 professionals, including a strong international network of clinical monitors and project managers, regulatory, data management, statistical, scientific, and medical experts. They are focused on smart study design for advanced medicines that allow life-changing treatments.

    Media Partners

    Pain News

    Official Media Partner

    The British Pain Society Newsletter Pain News is published quarterly and is edited by Dr Arasu Rayen. Members of the Society will receive a free copy and are encouraged to contribute to the content.

    The British Journal of Pain

    Official Media Partner

    The British Journal of Pain is the official journal of the British Pain Society. It provides scientists and clinicians in pain medicine with peer-reviewed review articles and expert opinions on all aspects of pain management from basic science to its clinical application including pain physiology, pharmacology and interventions. This journal provides content of multidisciplinary interest and reviews and forecasts important issues and trends in the management of acute and chronic pain.

    Media Partners


    Official Publication

    ACNR (Advances in Clinical Neuroscience & Rehabilitation) is one of the most widely read publications in the neurology field in the UK. It provides concise review articles, specialist reviews of core papers from international journals, conference news, book reviews, short accounts of best management practice, case reports, news of awards/appointments and more. This independently produced journal is available free of charge to members of the profession, and we welcome your input.

    Media Partners

    Centre for Human Drug Research

    Online Partner

    Since 1987, CHDR has developed into a unique research organisation specialising in early phase studies which combines knowledge and academic collaborations with operational excellence in clinical trial services. CHDR's strong track record in analgesic and pain research allows us to offer an efficient route towards proof of concept in patients.

    Media Partners



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    Technology Networks


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    Drug Target Review


    Drug Target Review’s quarterly magazine, website and annual events program provides high quality content with peer-written articles that are submitted exclusively by the world’s most respected scientists in their field. This attracts a committed base of readers, users and delegates made up of senior decision-makers from the life science and drug discovery industries at the top pharmaceutical companies, as well as academics and scientists from the top research institutes across the globe.

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    Swiss Biotech Association


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    MedNous is a print publication and website about medical innovation in Europe. It carries exclusive interviews with companies that are at the forefront of medical technology, as well as contributor articles from prominent practitioners. Our mission is to identify significant advances in medicine and to explain how this innovation is being commercialised. In doing so, we talk to venture capitalists about what products and platforms they are supporting. We report on how regulators cope with the accelerating pace of innovation. And we regularly cover the latest developments in the discovery and development of new medical concepts in the area of antibodies, vaccines, small molecules, regenerative medicine and nanomedicines. MedNous combines the English word for medicine with the Greek word for intellect. And those with nous are readers of our publication. Visit our website: www.mednous.com



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    Bentham Science


    Bentham Science Publishers is a major STM journal publisher of 130 plus print and online journal. Out of these, 40 journals have already registered good IMPACT FACTORS as per Journal Citation Reports® 2017. These titles have extensive readership mostly in Europe and North America. For a detailed profile please visit our website at http://www.benthamscience.com. Besides, Bentham Science publishes eBooks in all areas of Science, Technology and Medicine. Our eBooks provide professionals, academicians, corporate researchers, graduates and undergraduates worldwide with the most current information in their subject areas of interest. Our eBooks are also available in the ePub and Kindle formats besides the PDF edition here http://ebooks.benthamscience.com/. Bentham is offering attendees of this conference discounts on its publication. For more information click here



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    speaker image






    CPD stands for Continuing Professional Development’. It is essentially a philosophy, which maintains that in order to be effective, learning should be organised and structured. The most common definition is:

    ‘A commitment to structured skills and knowledge enhancement for Personal or Professional competence’

    CPD is a common requirement of individual membership with professional bodies and Institutes. Increasingly, employers also expect their staff to undertake regular CPD activities.

    Undertaken over a period of time, CPD ensures that educational qualifications do not become obsolete, and allows for best practice and professional standards to be upheld.

    CPD can be undertaken through a variety of learning activities including instructor led training courses, seminars and conferences, e:learning modules or structured reading.


    There are approximately 470 institutes in the UK across all industry sectors, with a collective membership of circa 4 million professionals, and they all expect their members to undertake CPD.

    For some institutes undertaking CPD is mandatory e.g. accountancy and law, and linked to a licence to practice, for others it’s obligatory. By ensuring that their members undertake CPD, the professional bodies seek to ensure that professional standards, legislative awareness and ethical practices are maintained.

    CPD Schemes often run over the period of a year and the institutes generally provide online tools for their members to record and reflect on their CPD activities.


    Professional bodies and Institutes CPD schemes are either structured as ‘Input’ or ‘Output’ based.

    ‘Input’ based schemes list a precise number of CPD hours that individuals must achieve within a given time period. These schemes can also use different ‘currencies’ such as points, merits, units or credits, where an individual must accumulate the number required. These currencies are usually based on time i.e. 1 CPD point = 1 hour of learning.

    ‘Output’ based schemes are learner centred. They require individuals to set learning goals that align to professional competencies, or personal development objectives. These schemes also list different ways to achieve the learning goals e.g. training courses, seminars or e:learning, which enables an individual to complete their CPD through their preferred mode of learning.

    The majority of Input and Output based schemes actively encourage individuals to seek appropriate CPD activities independently.

    As a formal provider of CPD certified activities, SAE Media Group can provide an indication of the learning benefit gained and the typical completion. However, it is ultimately the responsibility of the delegate to evaluate their learning, and record it correctly in line with their professional body’s or employers requirements.


    Increasingly, international and emerging markets are ‘professionalising’ their workforces and looking to the UK to benchmark educational standards. The undertaking of CPD is now increasingly expected of any individual employed within today’s global marketplace.

    CPD Certificates

    We can provide a certificate for all our accredited events. To request a CPD certificate for a conference , workshop, master classes you have attended please email events@saemediagroup.com

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